Glypican 3 antibody (Middle Region)
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- Target See all Glypican 3 (GPC3) Antibodies
- Glypican 3 (GPC3)
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Binding Specificity
- AA 345-370, Middle Region
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This Glypican 3 antibody is un-conjugated
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Application
- Immunofluorescence (IF), Enzyme Immunoassay (EIA)
- Specificity
- This antibody recognizes Human and Mouse Glypican 3 (GPC3). Other species not tested.
- Purification
- Protein G Column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS
- Immunogen
- KLH conjugated synthetic peptide selected from the center region of Human GPC3 (aa 345-370)
- Isotype
- Ig Fraction
- Top Product
- Discover our top product GPC3 Primary Antibody
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 0.25 mg/mL
- Buffer
- PBS containing 0.09 % (W/V) Sodium Azide as preservative
- Preservative
- Sodium azide
- Precaution of Use
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freezing and thawing.
- Storage
- 4 °C/-20 °C
- Storage Comment
- Store undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.
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- Target
- Glypican 3 (GPC3)
- Alternative Name
- Glypican-3 / GPC3 (GPC3 Products)
- Synonyms
- GPC3 antibody, sgb antibody, dgsx antibody, sdys antibody, sgbs antibody, oci-5 antibody, sgbs1 antibody, DGSX antibody, GTR2-2 antibody, MXR7 antibody, OCI-5 antibody, SDYS antibody, SGB antibody, SGBS antibody, SGBS1 antibody, Glypican-3 antibody, glypican 3 antibody, gpc3 antibody, GPC3 antibody, Gpc3 antibody
- Background
- GPC3 is a cell surface proteoglycan that bears heparan sulfate. This protein may be involved in the suppression/modulation of growth in the predominantly mesodermal tissues and organs, and may play a role in the modulation of IGF2 interactions with its receptor and thereby modulate its function. Members of the glypican-related integral membrane proteoglycan family contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol (GPI) linkage. These proteins may play a role in the control of cell division, growth regulation, and tumor predisposition. Deletion mutations in GPC3 are the cause of Simpson-Golabi-Behmel syndrome (SGBS), also known as Simpson dysmorphia syndrome (SDYS). SGBS is a condition characterized by pre- and postnatal overgrowth (gigantism) with visceral and skeletal anomalies.Synonyms: GTR2-2, Intestinal protein OCI-5, MXR7, OCI5
- Gene ID
- 2719, 9606
- UniProt
- P51654
- Pathways
- Glycosaminoglycan Metabolic Process
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