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ATG16L1 antibody (ATG16 Autophagy Related 16-Like 1 (S. Cerevisiae)) (AA 84-114)

Details for Product anti-ATG16L1 Antibody No. ABIN1449612, Supplier: Log in to see
Antigen
  • atg16
  • atg16l
  • APG16L
  • ATG16A
  • ATG16L
  • IBD10
  • WDR30
  • 1500009K01Rik
  • Apg16l
  • Atg16l
  • Wdr30
Epitope
AA 84-114
24
21
16
16
13
12
12
5
5
4
4
3
3
2
2
2
2
2
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine)
155
69
51
12
11
6
4
2
2
2
2
1
Host
Rabbit
135
17
14
2
Clonality
Polyclonal
Conjugate
This ATG16L1 antibody is un-conjugated
6
6
5
4
4
4
3
2
2
2
1
1
1
1
1
1
1
1
Application
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
125
62
33
26
19
16
14
6
6
5
4
1
1
Supplier
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Immunogen KLH conjugated synthetic peptide between 84~114 amino acids surrounding amino acid L92 of Human APG16L Genename: ATG16L1
Isotype Ig
Purification Saturated Ammonium Sulfate precipitation followed by dialysis against PBS
Alternative Name APG16L / ATG16L1 (ATG16L1 Antibody Abstract)
Background Macroautophagy is the major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane bound autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane bound structure, which then fuse with the lysosome (or vacuole) releasing a single-membrane bound autophagic bodies which are then degraded within the lysosome (or vacuole). The APG12-APG5-APG16L complex is esential for the elongation of autophagic isolation membranes. This complex initially associates in uniform distribution with small vesicle membranes. During membrane elongation, the complex partitions, with a great concentration building on the outer side of the isolation membrane. Upon completion of the formation of the autophagosome, the APG12-APG5-APG16L dissociates from the membrane.Synonyms: APG16-like 1, Autophagy-related protein 16-1
Molecular Weight 68265 Da
Gene ID 55054
NCBI Accession NP_001177195
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS containing 0.09 % (W/V) Sodium Azide as preservative
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Supplier Images
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-ATG16L1 antibody (ATG16 Autophagy Related 16-Like 1 (S. Cerevisiae)) (AA 84-114) (ABIN1449612) Formalin-fixed and paraffin-embedded human colon carcinoma tissue reacted with Autoph...
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-ATG16L1 antibody (ATG16 Autophagy Related 16-Like 1 (S. Cerevisiae)) (AA 84-114) (ABIN1449612) Paraformaldehyde-fixed paraffin-embedded biopsy from patient with confirmed colonic C...
Western Blotting (WB) image for anti-ATG16L1 antibody (ATG16 Autophagy Related 16-Like 1 (S. Cerevisiae)) (AA 84-114) (ABIN1449612) Western blot analysis using APG16L Antibody in Cos7, HEK293, MEF, and Hela cells, lef...
Western Blotting (WB) image for anti-ATG16L1 antibody (ATG16 Autophagy Related 16-Like 1 (S. Cerevisiae)) (AA 84-114) (ABIN1449612) Western blot analysis using APG16L Antibody in Mouse brain tissue lysate.
Western Blotting (WB) image for anti-ATG16L1 antibody (ATG16 Autophagy Related 16-Like 1 (S. Cerevisiae)) (AA 84-114) (ABIN1449612) Western blot analysis using APG16L Antibody  in NCI-H460 cell line lysates (35ug/lane...
Product cited in: Nomura, Uzawa, Yamano et al.: "Overexpression and altered subcellular localization of autophagy-related 16-like 1 in human oral squamous-cell carcinoma: correlation with lymphovascular invasion and lymph-node metastasis." in: Human pathology, Vol. 40, Issue 1, pp. 83-91, 2008 (PubMed).

Background publications Nascimento-Ferreira, Santos-Ferreira, Sousa-Ferreira et al.: "Overexpression of the autophagic beclin-1 protein clears mutant ataxin-3 and alleviates Machado-Joseph disease." in: Brain : a journal of neurology, Vol. 134, Issue Pt 5, pp. 1400-15, 2011 (PubMed).

Travassos, Carneiro, Ramjeet et al.: "Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entry." in: Nature immunology, Vol. 11, Issue 1, pp. 55-62, 2009 (PubMed).

Greenberg: "Degrade or die: a dual function for autophagy in the plant immune response." in: Developmental cell, Vol. 8, Issue 6, pp. 799-801, 2005 (PubMed).

Baehrecke: "Autophagy: dual roles in life and death?" in: Nature reviews. Molecular cell biology, Vol. 6, Issue 6, pp. 505-10, 2005 (PubMed).

Lum, DeBerardinis, Thompson: "Autophagy in metazoans: cell survival in the land of plenty." in: Nature reviews. Molecular cell biology, Vol. 6, Issue 6, pp. 439-48, 2005 (PubMed).

Levine: "Eating oneself and uninvited guests: autophagy-related pathways in cellular defense." in: Cell, Vol. 120, Issue 2, pp. 159-62, 2005 (PubMed).

Shintani, Klionsky: "Autophagy in health and disease: a double-edged sword." in: Science (New York, N.Y.), Vol. 306, Issue 5698, pp. 990-5, 2004 (PubMed).