ATG16 Autophagy Related 16-Like 1 (S. Cerevisiae) (ATG16L1) (C-Term), (AA 377-407) antibody

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Antigen
Synonyms atg16, atg16l, APG16L, ATG16A, ATG16L, IBD10, WDR30, 1500009K01Rik, Apg16l, Atg16l, Wdr30
Epitope
AA 377-407, C-Term
(21), (19), (15), (14), (13), (12), (12), (12), (5), (4), (3), (3), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1)
Reactivity
Human
(156), (76), (54), (12), (11), (6), (4), (2), (2), (2), (2), (1), (1)
Host
Rabbit
(134), (17), (16), (2)
Clonality
Polyclonal
Conjugate
Un-conjugated
(8), (8), (7), (5), (5), (5), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Application
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(130), (61), (36), (23), (20), (14), (13), (7), (6), (5), (4), (3), (2)
Pubmed 6 references available
Quantity 0.4 mL
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Immunogen KLH conjugated synthetic peptide between 377~407 amino acids from the C-term of Human APG16L Genename: ATG16L1
Isotype Ig
Purification Ammonium Sulfate precipitation followed by dialysis against PBS
Alternative Name APG16L / ATG16L1 (ATG16L1 Antibody Abstract)
Background Macroautophagy is the major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane bound autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane bound structure, which then fuse with the lysosome (or vacuole) releasing a single-membrane bound autophagic bodies which are then degraded within the lysosome (or vacuole). The APG12-APG5-APG16L complex is esential for the elongation of autophagic isolation membranes. This complex initially associates in uniform distribution with small vesicle membranes. During membrane elongation, the complex partitions, with a great concentration building on the outer side of the isolation membrane. Upon completion of the formation of the autophagosome, the APG12-APG5-APG16L dissociates from the membrane.Synonyms: APG16-like 1, Autophagy-related protein 16-1
Molecular Weight 68265 Da
Gene ID 55054
NCBI Accession NP_001177195
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS containing 0.09 % (W/V) Sodium Azide as preservative
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Background publications Gao, Kang, Liao et al.: "Biochemical isolation and characterization of the tubulovesicular LC3-positive autophagosomal compartment." in: The Journal of biological chemistry, Vol. 285, Issue 2, pp. 1371-83, 2010 (PubMed).

Greenberg: "Degrade or die: a dual function for autophagy in the plant immune response." in: Developmental cell, Vol. 8, Issue 6, pp. 799-801, 2005 (PubMed).

Baehrecke: "Autophagy: dual roles in life and death?" in: Nature reviews. Molecular cell biology, Vol. 6, Issue 6, pp. 505-10, 2005 (PubMed).

Lum, DeBerardinis, Thompson: "Autophagy in metazoans: cell survival in the land of plenty." in: Nature reviews. Molecular cell biology, Vol. 6, Issue 6, pp. 439-48, 2005 (PubMed).

Levine: "Eating oneself and uninvited guests: autophagy-related pathways in cellular defense." in: Cell, Vol. 120, Issue 2, pp. 159-62, 2005 (PubMed).

Shintani, Klionsky: "Autophagy in health and disease: a double-edged sword." in: Science (New York, N.Y.), Vol. 306, Issue 5698, pp. 990-5, 2004 (PubMed).

Validation Images
Catalog No. ABIN1449636
357.50 $
Plus shipping costs $45.00
Quantity
Price
0.4 mL
357.50 $

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