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CEP290 antibody (Internal Region)
CEP290
Reactivity: Human, Mouse
IF
Host: Goat
Polyclonal
unconjugated
Product Details anti-CEP290 Antibody
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Target
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CEP290
(Centrosomal Protein 290kDa (CEP290))
Binding Specificity
All epitopes for CEP290 antibodies
Internal Region
Reactivity
All reactivities for CEP290 antibodies
Human, Mouse
Host
All hosts for CEP290 antibodies
Goat
Clonality
All clonalities for CEP290 antibodies
Polyclonal
Conjugate
All conjugates for CEP290 antibodies
This CEP290 antibody is un-conjugated
Application
All applications for CEP290 antibodies
Immunofluorescence (IF)
Sequence
C-RNSKHLKQQQ YRAEN
Purification
Ammonium Sulphate Precipitation followed by Antigen Affinity Chromatography using the immunizing peptide
Immunogen
Peptide with sequence from the internal region of the protein sequence according to NP_079390.3. Genename: CEP290
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Alternatives
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Application Details
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Application Notes
Optimal working dilution should be determined by the investigator.
Restrictions
For Research Use only
Handling
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Concentration
0.5 mg/mL
Buffer
Tris saline, pH ~7.3, 0.02 % Sodium Azide, 0.5 % BSA
Preservative
Sodium azide
Precaution of Use
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice
Avoid repeated freezing and thawing.
Storage
4 °C/-20 °C
Storage Comment
Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Target Details for CEP290
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Target
CEP290
(Centrosomal Protein 290kDa (CEP290))
Alternative Name
CEP290 (CEP290 Products )
Synonyms
ct87 antibody, mks4 antibody, rd16 antibody, bbs14 antibody, jbts5 antibody, jbts6 antibody, lca10 antibody, nphp6 antibody, slsn6 antibody, sh11ag antibody, MGC81471 antibody, 3h11ag antibody, RGD1311640 antibody, BC004690 antibody, Nphp6 antibody, b2b1454Clo antibody, b2b1752Clo antibody, im:7145703 antibody, im:7147820 antibody, 3H11Ag antibody, BBS14 antibody, CT87 antibody, JBTS5 antibody, LCA10 antibody, MKS4 antibody, NPHP6 antibody, POC3 antibody, SLSN6 antibody, centrosomal protein 290 antibody, centrosomal protein 290 L homeolog antibody, centrosomal protein 290kDa antibody, CEP290 antibody, cep290.L antibody, cep290 antibody, Cep290 antibody
Background
CEP290 activates ATF4 mediated transcription and is required for the correct localization of ciliary and phototransduction proteins in retinal photoreceptor cells, may play a role in ciliary transport processes. CEP290 is ubiquitously expressed, strongly in placenta and weakly in brain. There are two named isoforms. Defects in CEP290 are a cause of Joubert syndrome type 5 (JBTS5) [MIM:610188], Senior-Loken syndrome type 6 (SLSN6) [MIM:610189], Leber congenital amaurosis type 10 (LCA10) [MIM:611755] and Meckel syndrome type 4 (MKS4) [MIM:611134]. Antibodies against CEP290 are present in sera from patients with cutaneous T cell lymphomas, but not in the healthy control population.Synonyms: CT87, Cancer/testis antigen 87, Centrosomal protein of 290 kDa, KIAA0373, NPHP6, Nephrocystin-6, Tumor antigen se2-2, se2-2
Gene ID
80184
NCBI Accession
NP_079390
Pathways
cAMP Metabolic Process , M Phase
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