AOC2 antibody (Middle Region)

Catalog No. ABIN1449831

Product Details anti-AOC2 Antibody

Target: AOC2 (Amine Oxidase, Copper Containing 2 (Retina-Specific) (AOC2))

Binding Specificity: Middle Region

Reactivity: Human, Mouse, Cow, Dog, Rat, Zebrafish (Danio rerio), Chicken, Xenopus laevis

Host: Rabbit

Clonality: Polyclonal

Conjugate: This AOC2 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: AEDIPNTVTL GNRVGFLLRP YNFFDEDPSI FSPGSVYFEK GQDAGLCSIN

Cross-Reactivity (Details): Species reactivity (expected):Mouse, Bovine, Rabbit, Dog, PigSpecies reactivity (tested):Human.

Purification: Purified using peptide immunoaffinity column

Immunogen: Synthetic peptide directed towards the middle region of human AOC2

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Reconstitution: Add 50 μL of distilled water to a final concentration of 1 mg/mL.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store lyophilized at 2-8 °C for one month or at -20 °C long term. After reconstitution store the antibody undiluted at 2-8 °C for up to one month or in aliquots at -20 °C long term.

Target Details for AOC2

Target: AOC2 (Amine Oxidase, Copper Containing 2 (Retina-Specific) (AOC2))

Alternative Name: AOC2 / RAO (AOC2 Products)

Background: Copper amine oxidases catalyze the oxidative conversion of amines to aldehydes and ammonia in the presence of copper and quinone cofactor. The protein contains several conserved motifs including the active site of amine oxidases and the histidine residues that likely bind copper. It may be a critical modulator of signal transmission in retina, possibly by degrading the biogenic amines dopamine, histamine, and putrescine. Copper amine oxidases catalyze the oxidative conversion of amines to aldehydes and ammonia in the presence of copper and quinone cofactor. This gene shows high sequence similarity to copper amine oxidases from various species ranging from bacteria to mammals. The protein contains several conserved motifs including the active site of amine oxidases and the histidine residues that likely bind copper. It may be a critical modulator of signal transmission in retina, possibly by degrading the biogenic amines dopamine, histamine, and putrescine. This gene may be a candidate gene for hereditary ocular diseases. Alternate splicing results in multiple transcript variants.Synonyms: Amine oxidase copper-containing, Retina-specific copper amine oxidase

Gene ID: 314

NCBI Accession: NP_033720