TMEM237 antibody (Middle Region)

Catalog No. ABIN1449912

Product Details anti-TMEM237 Antibody

Target: TMEM237 (Transmembrane Protein 237 (TMEM237))

Binding Specificity: Middle Region

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TMEM237 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: AGDQLSNLSN LLQQYKTLAY PFQSLLYLLL ALSTISAFDR IDFAKISVAI

Cross-Reactivity (Details): Species reactivity (tested):Human

Purification: Purified using peptide immunoaffinity column

Immunogen: Synthetic peptide directed towards the middle region of human ALS2CR4

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Reconstitution: Add 50 μL of distilled water to a final concentration of 1 mg/mL.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store lyophilized at 2-8 °C or at -20 °C long term. After reconstitution store the antibody undiluted at 2-8 °C for up to one month or in aliquots at -20 °C long term.

Target Details for TMEM237

Target: TMEM237 (Transmembrane Protein 237 (TMEM237))

Alternative Name: ALS2CR4 / TMEM237 (TMEM237 Products)

Synonyms: ALS2CR4 antibody, JBTS14 antibody, Als2cr4 antibody, AI853305 antibody, Gm972 antibody, als2cr4 antibody, als2cr4a antibody, si:dkey-33m14.6 antibody, als2cr4b antibody, sb:cb992 antibody, zgc:101660 antibody, transmembrane protein 237 antibody, transmembrane protein 237a antibody, transmembrane protein 237 L homeolog antibody, transmembrane protein 237b antibody, TMEM237 antibody, Tmem237 antibody, tmem237 antibody, tmem237a antibody, tmem237.L antibody, tmem237b antibody

Background: TMEM237 or ALS2CR4 is a component of the transition zone in primary cilia and required for ciliogenesis. Defects in TMEM237 are the cause of Joubert syndrome type 14 (JBTS14). An autosomal recessive disorder characterized by severe mental retardation, hypotonia, breathing abnormalities in infancy, and dysmorphic facial features. Neuroradiologically, it is characterized by cerebellar vermian hypoplasia/aplasia, thickened and reoriented superior cerebellar peduncles, and an abnormally large interpeduncular fossa, giving the appearance of a molar tooth on transaxial slices (molar tooth sign). Additional variable JBTS14 features include renal disease, abnormal eye movements, and postaxial polydactyly.Synonyms: Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 4 protein, Transmembrane protein 237

Gene ID: 65062

NCBI Accession: NM_001044385