DELE1/KIAA0141 antibody (N-Term)

Catalog No. ABIN1449949

Product Details anti-DELE1/KIAA0141 Antibody

Target: DELE1/KIAA0141 (DELE1) (DAP3 Binding Cell Death Enhancer 1 (DELE1))

Binding Specificity: N-Term

Reactivity: Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DELE1/KIAA0141 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)

Purification: Affinity chromatography purified via peptide column

Immunogen: 18 amino acid synthetic peptide near the amino terminus of Human DELE

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS containing 0.02 % Sodium Azide as preservative

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for DELE1/KIAA0141

Target: DELE1/KIAA0141 (DELE1) (DAP3 Binding Cell Death Enhancer 1 (DELE1))

Alternative Name: KIAA0141 (DELE1 Products)

Synonyms: KIAA0141 antibody, MGC139304 antibody, DELE antibody, 2700004E22Rik antibody, Dele antibody, Kiaa0141 antibody, KIAA0141 antibody, KIAA0141 ortholog antibody, RIKEN cDNA 0610009O20 gene antibody, SEL1 domain containing protein RGD735029 antibody, KIAA0141 antibody, 0610009O20Rik antibody, RGD735029 antibody

Background: DELE is a recently identified DAP3-binding protein that is thought to be important in the induction of death receptor-mediated apoptosis. Transfected cells that stably express DELE were found to be susceptible to apoptosis induction by TNF-alpha and TRAIL, whereas reducing DELE expression by siRNA rescued these cells from apoptosis induction. Furthermore, the reduction of DELE expression also inhibited the activation of caspase-3, caspase-8 and caspase-9 following stimulation by TNF-alpha, anti-Fas, or TRAIL, indicating the importance of DELE in apoptosis mediated by death receptors.

Gene ID: 9812

NCBI Accession: NP_055588