DISP2 antibody (N-Term)

Catalog No. ABIN1449961

Product Details anti-DISP2 Antibody

Target: DISP2 (Dispatched Homolog 2 (DISP2))

Binding Specificity: N-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DISP2 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Purification: Affinity chromatography purified via peptide column

Immunogen: 18 amino acid synthetic peptide near the amino terminus of Human DISP2

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS containing 0.02 % Sodium Azide as preservative

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for DISP2

Target: DISP2 (Dispatched Homolog 2 (DISP2))

Alternative Name: DISP2 / DISPB (DISP2 Products)

Synonyms: DISP2 antibody, DISPB antibody, HsT16908 antibody, AI840597 antibody, B230210L08Rik antibody, DispB antibody, mKIAA1742 antibody, dispatched RND transporter family member 2 antibody, dispatched RND tramsporter family member 2 antibody, dispatched homolog 2 (Drosophila) antibody, DISP2 antibody, Disp2 antibody

Background: DISP2 is the second of three known homologs of the D. melanogaster protein Dispatched. It is a multi-transmembrane protein containing two PTCH/DISP domains and is thought to be involved in the release of lipid-anchored Hedgehog from producing cells. Hedgehog is a major player in signaling pathways during embryogenesis, tissue regeneration, and carcinogenesis and the DISP proteins have been implicated in these pathways. Recently, it has been shown that DISP2 is translationally regulated by the microRNA miR-214 in zebrafish. Expression of this miRNA decreased DISP2 promoter activity in vitro and its overexpression in zebrafish resulted in a phenotype identical to that observed by DISP2 mutants.Synonyms: KIAA1742, Protein dispatched homolog 2

Gene ID: 85455

UniProt: A7MBM2

Pathways: Hedgehog Signaling