CARD14 antibody (C-Term)

Catalog No. ABIN1449966

Product Details anti-CARD14 Antibody

Target: CARD14 (Caspase Recruitment Domain Family, Member 14 (CARD14))

Binding Specificity: C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CARD14 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Purification: Affinity Chromatography purified via peptide column

Immunogen: 14 amino acid synthetic peptide near the carboxy terminus of Human CARMA2

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS containing 0.02 % Sodium Azide as preservative

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for CARD14

Target: CARD14 (Caspase Recruitment Domain Family, Member 14 (CARD14))

Alternative Name: CARD14 / CARMA2 (CARD14 Products)

Synonyms: BIMP2 antibody, CARMA2 antibody, PRP antibody, PSORS2 antibody, PSS1 antibody, Bimp2 antibody, caspase recruitment domain family member 14 antibody, caspase recruitment domain family, member 14 antibody, CARD14 antibody, Card14 antibody

Background: CARMA proteins belong to the membrane-associated guan-ylate kinase-like (MAGUK) family of proteins that can function as molecular scaffolds that assist assembly of signal transduction molecules. CARMA1, CARMA2, and CARMA3 share high degrees of sequence and functional homology, but their tissue-specific distribution suggests that they serve distinct biological functions in different cell types. As with CARMA1, the CARD domain of CARMA2 has been shown to specifically interact with BCL10, a protein known to function as a positive regulator of cell apoptosis and NF-kB activation. When expressed in cells, this protein activated NF-kB and induced the phosphorylation of BCL10 Alternative splicing of CARMA2 results in isoforms that possess differential effects on NF-kB activation and endoplasmic reticulum stress-induced cell death.Synonyms: CARD-containing MAGUK protein 2, Caspase recruitment domain-containing protein 14

Gene ID: 79092

NCBI Accession: NP_077015