ATG14 Autophagy Related 14 Homolog (S. Cerevisiae) (ATG14) (Middle Region) antibody

Details for Product No. ABIN1449976
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Antigen
Synonyms ATG14L, BARKOR, KIAA0831, 4832427M01, Atg14L, D14Ertd114e, D14Ertd436e, RGD1304610
Epitope
Middle Region
(7), (7), (1), (1), (1)
Reactivity
Human, Mouse (Murine), Rat (Rattus)
(18), (6), (6)
Host
Rabbit
(18)
Clonality
Polyclonal
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1)
Application
Immunocytochemistry (ICC), Immunofluorescence (IF), ELISA, Western Blotting (WB)
(18), (12), (8), (4), (1), (1)
Pubmed 5 references available
Quantity 0.1 mg
Shipping to United States (Change)
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Catalog No. ABIN1449976
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Immunogen ATG14 antibody was raised against an 18 amino acid synthetic peptide near the center of Human ATG14
Isotype IgG
Specificity At least three isoforms of ATG14 are known to exist. This antibody will detect all three isoforms.
Purification Affinity chromatography purified via peptide column
Alternative Name ATG14 / Barkor
Background Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components. This process is negatively regulated by TOR (Target of rapamycin) through phosphorylation of autophagy protein ATG1. ATG14 is a subunit of a class III phosphatidylinositol (PtdIns) 3-kinase complex that targets the complex to the endoplasmic reticulum, the site of autophagosome formation.
Alternate names: Atg14L, Beclin 1-associated autophagy-related key regulator, KIAA0831
Gene ID 22863
NCBI Accession NP_055739
Restrictions For Research Use only
Format Liquid
Concentration 1.0 mg/mL
Buffer PBS containing 0.02% Sodium Azide as preservative
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Background publications Kisen, Tessitore, Costelli et al.: "Reduced autophagic activity in primary rat hepatocellular carcinoma and ascites hepatoma cells." in: Carcinogenesis, Vol. 14, Issue 12, pp. 2501-5, 1994 (PubMed).

Kamada, Funakoshi, Shintani et al.: "Tor-mediated induction of autophagy via an Apg1 protein kinase complex." in: The Journal of cell biology, Vol. 150, Issue 6, pp. 1507-13, 2000 (PubMed).

Gozuacik, Kimchi: "Autophagy as a cell death and tumor suppressor mechanism." in: Oncogene, Vol. 23, Issue 16, pp. 2891-906, 2004 (PubMed).

Itakura, Kishi, Inoue et al.: "Beclin 1 forms two distinct phosphatidylinositol 3-kinase complexes with mammalian Atg14 and UVRAG." in: Molecular biology of the cell, Vol. 19, Issue 12, pp. 5360-72, 2008 (PubMed).

Matsunaga, Morita, Saitoh et al.: "Autophagy requires endoplasmic reticulum targeting of the PI3-kinase complex via Atg14L." in: The Journal of cell biology, Vol. 190, Issue 4, pp. 511-21, 2010 (PubMed).

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