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CDKN1C antibody (Cyclin-Dependent Kinase Inhibitor 1C (p57, Kip2)) (N-Term)

Details for Product anti-CDKN1C Antibody No. ABIN1449989, Supplier: Log in to see
Antigen
  • AL024410
  • BWCR
  • BWS
  • cb961
  • CDKI
  • DFNB48
  • Kip2
  • KIP2
  • p27Xic1-a
  • p57
  • p57(kip2)
  • p57Kip2
  • p57KIP2
  • USH1J
  • WBS
  • zgc:86618
Alternatives
anti-Human CDKN1C antibody for Immunohistochemistry (Paraffin-embedded Sections)
Epitope
N-Term
37
21
13
5
5
2
2
2
2
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
140
46
25
3
2
1
1
Host
Rabbit
102
48
Clonality
Polyclonal
Conjugate
This CDKN1C antibody is un-conjugated
5
3
3
2
2
2
1
1
1
1
1
1
1
1
1
Application
Enzyme Immunoassay (EIA), Immunofluorescence (IF), Western Blotting (WB)
84
51
36
35
22
15
12
4
1
1
Supplier
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Immunogen A 17 amino acid synthetic peptide near the amino terminus of Human CDKN1C
Isotype IgG
Purification Affinity chromatography purified via peptide column
Alternative Name CDKN1C / KIP2 (CDKN1C Antibody Abstract)
Background The cyclin-dependent kinase inhibitor 1C (CDKN1C), also known as p57KIP2, is a tight-binding, strong inhibitor of several G1 cyclin/CDK complexes and a negative regulator of cell proliferation. Mutations in this gene are implicated in sporadic cancers and Beckwith-Wiedemann syndrome, a cancer-predisposing syndrome, suggesting that this gene is a tumor suppressor candidate. CDKN1C is widely expressed during organogenesis with its expression declining after maturity. It is part of the CIP/KIP family of cyclin-dependent inhibitors (CKIs) which also includes CDKN1A and CDKN1B.Synonyms: Cyclin-dependent kinase inhibitor 1C, Cyclin-dependent kinase inhibitor p57, p57KIP2
Molecular Weight 35 kDa
Gene ID 1028
NCBI Accession NP_000067
Pathways Cell Division Cycle
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Concentration 1.0 mg/mL
Buffer PBS containing 0.02 % Sodium Azide as preservative
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Supplier Images
Western Blotting (WB) image for anti-CDKN1C antibody (Cyclin-Dependent Kinase Inhibitor 1C (p57, Kip2)) (N-Term) (ABIN1449989)

Western blot analysis of CDKN1C in 293 cell lysate with CDKN1C Antibody  at (A) 1 ...

Background publications Pateras, Apostolopoulou, Niforou, Kotsinas, Gorgoulis: "p57KIP2: \Kip\"ing the cell under control."" in: Molecular cancer research : MCR, Vol. 7, Issue 12, pp. 1902-19, 2009

Hatada, Ohashi, Fukushima, Kaneko, Inoue, Komoto, Okada, Ohishi, Nabetani, Morisaki, Nakayama, Niikawa, Mukai: "An imprinted gene p57KIP2 is mutated in Beckwith-Wiedemann syndrome." in: Nature genetics, Vol. 14, Issue 2, pp. 171-3, 1996

Lee, Reynisdóttir, Massagué: "Cloning of p57KIP2, a cyclin-dependent kinase inhibitor with unique domain structure and tissue distribution." in: Genes & development, Vol. 9, Issue 6, pp. 639-49, 1995