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BCL6 antibody (Middle Region)
BCL6
Reactivity: Human, Mouse, Rat
WB, EIA
Host: Rabbit
Polyclonal
unconjugated
Product Details anti-BCL6 Antibody
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Target
See all BCL6 Antibodies
BCL6
(B-Cell CLL/lymphoma 6 (BCL6))
Binding Specificity
All epitopes for BCL6 antibodies
Middle Region
Reactivity
All reactivities for BCL6 antibodies
Human, Mouse, Rat
Host
All hosts for BCL6 antibodies
Rabbit
Clonality
All clonalities for BCL6 antibodies
Polyclonal
Conjugate
All conjugates for BCL6 antibodies
This BCL6 antibody is un-conjugated
Application
All applications for BCL6 antibodies
Western Blotting (WB), Enzyme Immunoassay (EIA)
Purification
Affinity chromatography purified via peptide column
Immunogen
BCL6 antibody was raised against an 18 amino acid synthetic peptide near the center of Human BCL6
Isotype
IgG
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Alternatives
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Application Details
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Application Notes
Optimal working dilution should be determined by the investigator.
Restrictions
For Research Use only
Handling
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Concentration
1.0 mg/mL
Buffer
PBS containing 0.02 % Sodium Azide as preservative
Preservative
Sodium azide
Precaution of Use
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice
Avoid repeated freezing and thawing.
Storage
4 °C/-20 °C
Storage Comment
Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Target Details for BCL6
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Target
BCL6
(B-Cell CLL/lymphoma 6 (BCL6))
Alternative Name
Bcl-6 (BCL6 Products )
Synonyms
bcl5 antibody, laz3 antibody, bcl6a antibody, znf51 antibody, zbtb27 antibody, MGC132260 antibody, Bcl5 antibody, BCL5 antibody, BCL6A antibody, LAZ3 antibody, ZBTB27 antibody, ZNF51 antibody, B-cell CLL/lymphoma 6 L homeolog antibody, B-cell CLL/lymphoma 6 antibody, B cell leukemia/lymphoma 6 antibody, bcl6.L antibody, bcl6 antibody, BCL6 antibody, Bcl6 antibody
Background
BCL6 was first identified as a proto-oncogene in diffuse large B cell lymphoma. BCL6, a transcriptional repressor, plays an important role in lymphomagenesis. It binds Stat recognition-like DNA elements and is required for affinity maturation of mature B cells in germinal centers and Th1/Th2 differentiation, a process that critically depends on BCL6-mediated transcriptional repression of p53. BCL6 is a pharmacological target for eradication of leukemia-initiating cells in chronic myeloid leukemia (CML).Synonyms: B-cell lymphoma 6 protein, BCL-5, BCL5, BCL6, LAZ-3, LAZ3, ZBTB27, ZNF51, Zinc finger and BTB domain-containing protein 27, Zinc finger protein 51
Molecular Weight
78 kDa
Gene ID
604
NCBI Accession
NP_001124317
Pathways
Chromatin Binding , Regulation of Leukocyte Mediated Immunity , Production of Molecular Mediator of Immune Response , Protein targeting to Nucleus
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