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DDX60 antibody (Middle Region)

DDX60 Reactivity: Human, Mouse, Rat WB, IF, EIA Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN1450010
  • Target See all DDX60 Antibodies
    DDX60 (DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 60 (DDX60))
    Binding Specificity
    • 1
    • 1
    Middle Region
    Reactivity
    Human, Mouse, Rat
    Host
    • 2
    • 1
    Rabbit
    Clonality
    • 2
    • 1
    Polyclonal
    Conjugate
    • 3
    This DDX60 antibody is un-conjugated
    Application
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)
    Cross-Reactivity (Details)
    Species reactivity (tested):Human, Mouse, Rat.
    Purification
    Affinity chromatography purified via peptide column
    Immunogen
    17 amino acid synthetic peptide near the center of Human DDX60
    Isotype
    IgG
    Top Product
    Discover our top product DDX60 Primary Antibody
  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Concentration
    1.0 mg/mL
    Buffer
    PBS containing 0.02 % Sodium Azide as preservative
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    4 °C/-20 °C
    Storage Comment
    Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • Target
    DDX60 (DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 60 (DDX60))
    Alternative Name
    DDX60 (DDX60 Products)
    Synonyms
    9830118M07 antibody, RGD1560014 antibody, DExD/H-box helicase 60 antibody, DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 antibody, DEXD/H-box helicase 60 antibody, DDX60 antibody, Ddx60 antibody
    Background
    DDX60 is a DEXD/H Box RNA helicase and the human homolog of the S. cerevisiae Ski2, a cofactor of RNA exosome. Expression of DDX60 increases after viral infection and binds to endogenous RIG-I, a cytoplasmic viral RNA sensor, as well as other RIG-I-like receptors such as MDA5 and LGP2. These proteins activate TBK1 and IKK-e, signaling IRF3 and NF-kB-responsive genes in the innate immune response pathway. DDX60 is required for the RIG-I- or MDA5-dependent response to viral infection, but is dispensable for TLR3-mediated signaling.Synonyms: FLJ20035, Probable ATP-dependent RNA helicase DDX60
    Molecular Weight
    188 kDa
    Gene ID
    55601
    NCBI Accession
    NP_060101
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