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PIWIL2 antibody (Middle Region)

PIWIL2 Reactivity: Human, Mouse WB, EIA Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN1450077
  • Target See all PIWIL2 Antibodies
    PIWIL2 (Piwi-Like 2 (PIWIL2))
    Binding Specificity
    • 14
    • 8
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Middle Region
    Reactivity
    • 30
    • 10
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Human, Mouse
    Host
    • 31
    • 3
    • 1
    Rabbit
    Clonality
    • 33
    • 2
    Polyclonal
    Conjugate
    • 18
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This PIWIL2 antibody is un-conjugated
    Application
    • 25
    • 17
    • 5
    • 2
    • 2
    • 2
    • 2
    Western Blotting (WB), Enzyme Immunoassay (EIA)
    Purification
    Affinity chromatography purified via peptide column
    Immunogen
    17 amino acid synthetic peptide near the center of Human PIWI-L2
    Isotype
    IgG
    Top Product
    Discover our top product PIWIL2 Primary Antibody
  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Concentration
    1.0 mg/mL
    Buffer
    PBS containing 0.02 % Sodium Azide as preservative
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    4 °C/-20 °C
    Storage Comment
    Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • Target
    PIWIL2 (Piwi-Like 2 (PIWIL2))
    Alternative Name
    PIWIL2 (PIWIL2 Products)
    Synonyms
    si:dkey-88f5.1 antibody, zili antibody, Piwil1l antibody, mili antibody, CT80 antibody, HILI antibody, PIWIL1L antibody, piwil2 antibody, piwi like RNA-mediated gene silencing 2 antibody, piwi-like RNA-mediated gene silencing 2 antibody, piwil2 antibody, Piwil2 antibody, PIWIL2 antibody
    Background
    PIWI-L2 is a member of the PIWI subfamily of Argonaute proteins, evolutionarily conserved proteins containing both PAZ and Piwi motifs that are crucial for the biogenesis and function of small non-coding RNAs and play important roles in stem cell self-renewal, RNA silencing, and translational regulation in diverse organisms. PIWI-L2 has been implicated in multiple roles including stem cell self-renewal and is highly expressed in many breast cancers. In these tumors, PIWI-L2 silences the expression of STAT3, a regulator of Bcl-XL and cyclin D1, allowing the proliferation and survival of breast cancer stem cells. Recent studies have shown that overexpression of PIWI-like proteins are potential biomarkers for colon and other cancers.Synonyms: CT80, Cancer/testis antigen 80, HILI, Hiwi-like, Mili, Miwi-like, PIWIL1L, Piwi-like protein 2
    Gene ID
    55124
    NCBI Accession
    NP_00129193
    Pathways
    Stem Cell Maintenance
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