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TLR4 antibody (Toll-Like Receptor 4) (C-Term)

Details for Product anti-TLR4 Antibody No. ABIN1450149, Supplier: Log in to see
Antigen
  • ARMD10
  • CD284
  • Lps
  • Ly87
  • Ran/M1
  • Rasl2-8
  • TLR-4
  • TOLL
Alternatives
anti-Human TLR4 antibody for Flow Cytometry
Epitope
C-Term
41
38
31
26
15
15
14
13
13
12
11
10
10
7
7
6
5
5
5
5
5
4
3
3
3
2
2
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
475
201
119
64
44
43
35
24
9
7
3
1
Host
Rabbit
262
248
55
10
Clonality
Polyclonal
Conjugate
This TLR4 antibody is un-conjugated
47
43
40
15
12
11
11
8
8
8
7
7
6
6
6
6
5
4
4
4
4
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
Application
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
365
278
125
122
120
104
95
90
45
32
24
24
16
12
11
7
4
4
3
2
1
1
1
1
1
Supplier
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Immunogen 14 amino acid synthetic peptide near the carboxy terminus of Human TLR4
Isotype IgG
Purification Affinity chromatography purified via peptide column
Alternative Name CD284 / TLR4 (TLR4 Antibody Abstract)
Background Toll-like receptors (TLRs) are signaling molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. These proteins act through adaptor molecules such as MyD88 and TIRAP to activate various kinases and transcription factors such as Protein Kinase C (PKC) alpha/beta and NF-kB. Studies with TLR4-deficient mice indicate that the main ligand for TLR is lipopolysaccharide. Consequently, these mice also showed increased susceptibility to Gram-negative sepsis.Synonyms: Toll-like receptor 4
Gene ID 7099
NCBI Accession NP_612564
Research Area Signaling, Immunology, Inflammation
Pathways TLR Signaling
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Concentration 1.0 mg/mL
Buffer PBS containing 0.02 % Sodium Azide as preservative
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Background publications Vogel, Fitzgerald, Fenton: "TLRs: differential adapter utilization by toll-like receptors mediates TLR-specific patterns of gene expression." in: Molecular interventions, Vol. 3, Issue 8, pp. 466-77, 2004 (PubMed).