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TLR4 antibody (Toll-Like Receptor 4) (C-Term)

Details for Product anti-TLR4 Antibody No. ABIN1450149, Supplier: Log in to see
Antigen
  • ARMD10
  • CD284
  • TLR-4
  • TOLL
  • Lps
  • Ly87
  • Ran/M1
  • Rasl2-8
  • toll-like receptor 4
  • TLR4
  • Tlr4
Alternatives
anti-Human TLR4 antibody for Flow Cytometry
Epitope
C-Term
42
37
30
26
16
16
16
15
14
13
13
12
11
10
8
6
5
5
5
5
5
5
4
3
3
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
502
247
141
75
51
50
43
26
12
10
4
2
2
1
1
Host
Rabbit
283
254
55
10
Clonality
Polyclonal
Conjugate
This TLR4 antibody is un-conjugated
49
43
40
16
13
12
12
8
8
8
7
7
6
6
6
6
5
5
5
4
4
4
3
3
3
3
3
3
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
Application
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
371
295
133
132
124
108
96
96
34
27
26
24
21
16
12
8
7
4
4
3
3
2
2
1
1
1
1
Options
Supplier
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Immunogen 14 amino acid synthetic peptide near the carboxy terminus of Human TLR4
Isotype IgG
Purification Affinity chromatography purified via peptide column
Alternative Name CD284 / TLR4 (TLR4 Antibody Abstract)
Background Toll-like receptors (TLRs) are signaling molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. These proteins act through adaptor molecules such as MyD88 and TIRAP to activate various kinases and transcription factors such as Protein Kinase C (PKC) alpha/beta and NF-kB. Studies with TLR4-deficient mice indicate that the main ligand for TLR is lipopolysaccharide. Consequently, these mice also showed increased susceptibility to Gram-negative sepsis.Synonyms: Toll-like receptor 4
Gene ID 7099
NCBI Accession NP_612564
Research Area Signaling, Immunology, Inflammation
Pathways TLR Signaling, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Concentration 1.0 mg/mL
Buffer PBS containing 0.02 % Sodium Azide as preservative
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Background publications Vogel, Fitzgerald, Fenton: "TLRs: differential adapter utilization by toll-like receptors mediates TLR-specific patterns of gene expression." in: Molecular interventions, Vol. 3, Issue 8, pp. 466-77, 2004 (PubMed).