Toll-Like Receptor 8 (TLR8) (N-Term) antibody

Details for Product No. ABIN1450150
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Antigen
Synonyms CD288
Epitope
N-Term
(25), (13), (13), (7), (7), (6), (6), (4), (2), (2), (1), (1)
Reactivity
Human
(156), (64), (25), (17), (17)
Host
Rabbit
(106), (44), (20), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(16), (10), (9), (9), (8), (8), (5), (4), (4), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), ELISA
(100), (56), (49), (48), (21), (20), (14), (13), (7)
Pubmed 2 references available
Quantity 0.1 mg
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Catalog No. ABIN1450150
357.50 $
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Immunogen 13 amino acid synthetic peptide near the amino terminus of human TLR8
Isotype IgG
Specificity At least three isoforms of TLR8 are known to exist. This antibody is predicted not to cross- react with other TLR protein family members.
Purification Affinity chromatography purified via peptide column
Alternative Name CD288 / TLR8
Background Toll-like receptors (TLRs) are signaling molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. These proteins act through adaptor molecules such as MyD88 and TIRAP to activate various kinases and transcription factors. Like TLR7, TLR8 is localized to endosomal or lysosomal compartments and stimulates the innate immune response after activation by guanosine- and uridine-rich single-stranded RNA. Human but not murine TLR8 confers responsiveness to the antiviral compound R-848.
Alternate names: Toll-like receptor 8, UNQ249/PRO286
Gene ID 51311
NCBI Accession NP_619542
Research Area Signaling, Inflammation, Immunology
Restrictions For Research Use only
Format Liquid
Concentration 1.0 mg/mL
Buffer PBS containing 0.02% Sodium Azide as preservative
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Background publications Takeda, Kaisho, Akira: "Toll-like receptors." in: Annual review of immunology, Vol. 21, pp. 335-76, 2003 (PubMed).

Vogel, Fitzgerald, Fenton: "TLRs: differential adapter utilization by toll-like receptors mediates TLR-specific patterns of gene expression." in: Molecular interventions, Vol. 3, Issue 8, pp. 466-77, 2004 (PubMed).

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