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Toll-Like Receptor 8 (TLR8) (N-Term) antibody

Details for Product No. ABIN1450150, Supplier: Log in to see
Antigen
  • CD288
Alternatives
anti-Human Toll-Like Receptor 8 antibody for Western Blotting
Epitope
N-Term
43
24
20
18
15
14
10
5
5
4
3
3
2
2
1
1
1
1
Reactivity
Human
189
77
35
Host
Rabbit
163
43
10
2
Clonality
Polyclonal
Conjugate
Un-conjugated
17
15
13
8
8
7
5
5
4
1
1
1
1
1
1
1
Application
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
137
88
75
41
26
13
11
9
7
4
3
Supplier
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Immunogen 13 amino acid synthetic peptide near the amino terminus of human TLR8
Isotype IgG
Purification Affinity chromatography purified via peptide column
Alternative Name CD288 / TLR8 (TLR8 Antibody Abstract)
Background Toll-like receptors (TLRs) are signaling molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. These proteins act through adaptor molecules such as MyD88 and TIRAP to activate various kinases and transcription factors. Like TLR7, TLR8 is localized to endosomal or lysosomal compartments and stimulates the innate immune response after activation by guanosine- and uridine-rich single-stranded RNA. Human but not murine TLR8 confers responsiveness to the antiviral compound R-848.Synonyms: Toll-like receptor 8, UNQ249/PRO286
Gene ID 51311
NCBI Accession NP_619542
Research Area Signaling, Inflammation, Immunology
Pathways TLR Signaling
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Concentration 1.0 mg/mL
Buffer PBS containing 0.02 % Sodium Azide as preservative
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Background publications Vogel, Fitzgerald, Fenton: "TLRs: differential adapter utilization by toll-like receptors mediates TLR-specific patterns of gene expression." in: Molecular interventions, Vol. 3, Issue 8, pp. 466-77, 2004 (PubMed).

Takeda, Kaisho, Akira: "Toll-like receptors." in: Annual review of immunology, Vol. 21, pp. 335-76, 2003 (PubMed).