PHOX2B antibody (Middle Region)

Catalog No. ABIN1450171

Product Details anti-PHOX2B Antibody

Target: PHOX2B (Paired-Like Homeobox 2b (PHOX2B))

Binding Specificity: Middle Region

Reactivity: Mouse, Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PHOX2B antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Purification: Affinity chromatography purified via peptide column

Immunogen: 15 amino acid synthetic peptide near the center of Human PHOX2B

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS containing 0.02 % Sodium Azide as preservative

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for PHOX2B

Target: PHOX2B (Paired-Like Homeobox 2b (PHOX2B))

Alternative Name: PHOX2B (PHOX2B Products)

Synonyms: phox2 antibody, xphox2b antibody, phox2b antibody, PHOX2B antibody, pmx2b antibody, nbphox antibody, NBLST2 antibody, NBPhox antibody, PMX2B antibody, Dilp1 antibody, Pmx2b antibody, paired-like homeobox 2b antibody, paired like homeobox 2b S homeolog antibody, paired-like homeobox 2bb antibody, paired like homeobox 2b antibody, phox2b antibody, phox2b.S antibody, phox2bb antibody, PHOX2B antibody, Phox2b antibody

Background: PHOX2A and PHOX2B (Paired mesoderm homeobox protein) are closely related, paired-homeodomain transcription factors that function as determinants of the noradrenergic phenotype during embryogenesis. PHOX2 proteins are crucial for the regulation of endogenous hydroxylases in neural crest cells and promote sympathetic neuron generation. Human PHOX2B contains one DNA binding homeobox domain and is required for the differentiation of all central and nonperipheral noradrenergic centers in the brain. In contrast, PHOX2A controls only the differentiation of the main noradrenergic center of the brain. Regulation of PHOX2 may have therapeutic utility in aging or disorders involving degeneration of noradrenergic neurons .Synonyms: NBPhox, Neuroblastoma Phox, PHOX2B homeodomain protein, PMX2B, Paired mesoderm homeobox protein 2B, Paired-like homeobox 2B

Gene ID: 8929

NCBI Accession: NP_003915