Cytokeratin 1 (KRT1) (pan) antibody

Details for Product No. ABIN145492
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Synonyms EpK, cytok, cytokeratin, epi-keratin, epiker, xK81
(59), (7), (1), (1), (1), (1), (1), (1)
(94), (17), (11), (9), (6), (5), (5), (4), (4), (3), (2), (1), (1), (1), (1), (1), (1)
(88), (9), (4), (1)
Clonality (Clone)
Monoclonal ()
(3), (2), (1), (1)
Immunohistochemistry (Acetone-fixed) (IHC (af)), Dot Blot (DB), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (IHC), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(52), (49), (34), (32), (32), (21), (20), (13), (7), (3), (2), (2), (2), (1)
Pubmed 3 references available
Quantity 0.1 mL
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Catalog No. ABIN145492
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Immunogen Full length native protein (purified) (Human epidermis).
Clone PCK-26
Isotype IgG1
Specificity PCK-26 recognizes the 58 kDa cytokeratin 5, the 56 kDa cytokeratin 6 and the 52 kDa cytokeratin 8 band in immunoblotting (Lane EB et al). It reacts specifically with a wide variety of normal, reactive and neoplastic epithelial tissues. The antibody reacts with simple, cornifying and non-cornifying squamous epithelia and pseudostratified epithelia. It does not react with non-epithelial normal human tissues.
Cross-Reactivity Mouse (Murine), Cow (Bovine), Goat, Rabbit, Rat (Rattus), Sheep (Ovine)
Purification Ascites.
Alternative Name Cytokeratin
Background Cytokeratins, a group comprising at least 29 different proteins, are characteristic of epithelial and trichocytic cells. Cytokeratin 5, 6 and 8 are members of the type II neutral-to-basic subfamily. Monoclonal antibodies to cytokeratins are specific markers of epithelial cell differentiation and have been widely used as tools in tumor identification and classification. PCK-26 facilitates the typing of normal, metaplastic and neoplastic cells and it may aid in the discrimination of carcinomas and non-epithelial tumors such as sarcomas, lymphomas and neural tumors. It is also useful in detecting micro-metastases in lymph nodes and other tissues and for determining the origin of poorly differentiated tumors (1,2).
Research Area Extracellular Matrix
Application Notes AF: Use at an assay dependant dilution. Dot: Use at an assay dependant dilution. IHC-F: Use at an assay dependant dilution. IF: Use at a dilution of 1/300. IHC-P: Use at an assay dependant dilution. IHC-Fr: Use at an assay dependant dilution. WB: Use at an assay dependant dilution. Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user.
Restrictions For Research Use only
Format Liquid
Buffer Ascitic fluid with 0.1% sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid freeze-thaw cycles.
Storage 4 °C
Storage Comment Keep as concentrated solution. Store at 4°C short term. For extended storage aliquot and store at -20°C or below.
General Moll, Franke, Schiller et al.: "The catalog of human cytokeratins: patterns of expression in normal epithelia, tumors and cultured cells." in: Cell, Vol. 31, Issue 1, pp. 11-24, 1983 (PubMed).

Lane, Alexander: "Use of keratin antibodies in tumor diagnosis." in: Seminars in cancer biology, Vol. 1, Issue 3, pp. 165-79, 1991 (PubMed).

Lane, Rugg, Navsaria et al.: "A mutation in the conserved helix termination peptide of keratin 5 in hereditary skin blistering." in: Nature, Vol. 356, Issue 6366, pp. 244-6, 1992 (PubMed).

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