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Details for Product No. ABIN145492

Cytokeratin 1 (KRT1) (pan) antibody

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Antigen
Synonyms EpK, cytok, cytokeratin, epi-keratin, epiker, xK81
Epitope
Reactivity
»Alternatives Chicken
Host
»Alternatives Mouse
Clonality Monoclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Dot Blot (DB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB), Immunohistochemistry (IHC)
Pubmed 3 references available
Catalog no. ABIN145492
Quantity 0.1 mL
Price
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Immunogen Full length native protein (purified) (Human epidermis).
Isotype IgG1
Specificity PCK-26 recognizes the 58 kDa cytokeratin 5, the 56 kDa cytokeratin 6 and the 52 kDa cytokeratin 8 band in immunoblotting (Lane EB et al). It reacts specifically with a wide variety of normal, reactive and neoplastic epithelial tissues. The antibody reacts
Cross-Reactivity Goat, Mouse (Murine), Rabbit, Rat (Rattus), Sheep (Ovine)
Purification Ascites
Alternative Name Cytokeratin
Background Cytokeratins, a group comprising at least 29 different proteins, are characteristic of epithelial and trichocytic cells. Cytokeratin 5, 6 and 8 are members of the type II neutral-to-basic subfamily. Monoclonal antibodies to cytokeratins are specific markers of epithelial cell differentiation and have been widely used as tools in tumor identification and classification. PCK-26 facilitates the typing of normal, metaplastic and neoplastic cells and it may aid in the discrimination of carcinomas and non-epithelial tumors such as sarcomas, lymphomas and neural tumors. It is also useful in detecting micro-metastases in lymph nodes and other tissues and for determining the origin of poorly differentiated tumors (1,2).
Research Area Extracellular Matrix
Application Notes AF: Use at an assay dependant dilution. Dot: Use at an assay dependant dilution. IHC-F: Use at an assay dependant dilution. IF: Use at a dilution of 1/300. IHC-P: Use at an assay dependant dilution. IHC-Fr: Use at an assay dependant dilution. WB: Use at an assay dependant dilution. Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user.
Restrictions For Research Use only
Format Liquid
Concentration Ascites Fluid
Buffer Ascitic fluid with 0.1% sodium azide
Preservative Sodium azide
Lane, Rugg, Navsaria et al.: "A mutation in the conserved helix termination peptide of keratin 5 in hereditary skin blistering." in: Nature, Vol. 356, Issue 6366, pp. 244-6, 1992 (PubMed).

Lane, Alexander: "Use of keratin antibodies in tumor diagnosis." in: Seminars in cancer biology, Vol. 1, Issue 3, pp. 165-79, 1991 (PubMed).

Moll, Franke, Schiller et al.: "The catalog of human cytokeratins: patterns of expression in normal epithelia, tumors and cultured cells." in: Cell, Vol. 31, Issue 1, pp. 11-24, 1983 (PubMed).

Alternatives for antigen "Cytokeratin 1 (KRT1)", type "Antibodies"
Hosts (57), (1), (1)
Reactivities (57), (7), (7), (4), (3), (3), (2), (1), (1), (1), (1), (1)
Applications (32), (19), (17), (17), (14), (9), (5), (3), (2), (2), (2), (1)
Conjugates (1), (1), (1)
Epitopes (23), (7)
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