Dynein, Axonemal, Heavy Chain 9 (DNAH9) (Cytoplasmic Domain) antibody

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Synonyms DNAH17L, DNEL1, DYH9, Dnahc9, HL-20, HL20, 9030022M04, A230091C01, C230051G16, D11Ertd686e, mKIAA0357, Bv2
Cytoplasmic Domain
(14), (12), (12), (12)
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Immunofluorescence (IF), Western Blotting (WB), ELISA
(10), (3), (3), (2), (1)
Pubmed 4 references available
Catalog no. ABIN145956
Quantity 0.1 mL
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Immunogen Cytoplasmic full length native protein (purified from chick brain) (Chicken).
Isotype IgG2a
Specificity The antibody identifies the cytoplasmic dynein heavy chain (440 kDa) in immunoblotting with dynein enriched preparations and in crude cell extracts of chicken brain and fibroblasts.
Cross-Reactivity Human
Purification Ascites
Alternative Name DNAH9
Background Eukaryotic cells rely on actin and microtubule-based protein ""motors"" to generate intracellular movements (3). These protein ""motors"" contain specialized domains that hydrolyze ATP to produce force and movement along a cytoskeletal polymer (actin in the case of myosin family and microtubules in the case of the kinesin family and dyneins). Dynein has been implicated in cytoplasmic motile functions, including chromosomal movement, retrograde organelle and axonal transport, the endocytic pathway, and the organization of the Golgi apparatus. In all cell types, dynein has the same basic structures and is composed of two or three distinct heavy chains (~450 kD), three intermediate chains (70-125 kD), and at least four light chains (15-25 kD) (4).
Application Notes ELISA: Use at an assay dependant dilution. IF: Use at an assay dependant dilution. WB (colorimetric): Use at a dilution of 1/100 for chick brain extract. Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user.
Restrictions For Research Use only
Format Liquid
Buffer Ascitic fluid with 0.1% sodium azide
Preservative Sodium azide
Storage -20 °C
General Wordeman, Steuer, Sheetz et al.: "Chemical subdomains within the kinetochore domain of isolated CHO mitotic chromosomes." in: The Journal of cell biology, Vol. 114, Issue 2, pp. 285-94, 1991 (PubMed).

Mocz, Farias, Gibbons: "Proteolytic analysis of domain structure in the beta heavy chain of dynein from sea urchin sperm flagella." in: Biochemistry, Vol. 30, Issue 29, pp. 7225-31, 1991 (PubMed).

Steuer, Wordeman, Schroer et al.: "Localization of cytoplasmic dynein to mitotic spindles and kinetochores." in: Nature, Vol. 345, Issue 6272, pp. 266-8, 1990 (PubMed).

Vallee, Shpetner: "Motor proteins of cytoplasmic microtubules." in: Annual review of biochemistry, Vol. 59, pp. 909-32, 1990 (PubMed).

Hosts (14)
Reactivities (14), (12), (12), (12)
Applications (10), (3), (3), (2), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (2)
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