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Details for Product No. ABIN145960

Collagen, Type VII (COL7) antibody

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Synonyms COL7A1
»Alternatives Cow (Bovine)
»Alternatives Mouse
Clonality Monoclonal
»Alternatives Un-conjugated
»Alternatives Dot Blot (DB), Immunofluorescence (IF), Western Blotting (WB), Immunohistochemistry (IHC), ELISA
Pubmed 7 references available
Catalog no. ABIN145960
Quantity 0.1 mL
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Immunogen Full length native protein (purified) (Human). Insoluble fractions prepared from neonatal foreskin epidermal cells.
Isotype IgG1
Specificity Reactive in immunoblotting against intact tissue Type VII collagen (250kD). Pepsin digestion of terminal regions leads to complte loss of reactivity. Antibody reactivity is conserved after treatment with collagenase.No reactivity against collagen types I,
Cross-Reactivity Horse (Equine), Guinea Pig, Goat, Human, Sheep (Ovine)
Purification Ascites
Alternative Name Collagen type VII
Background Mouse monoclonal [LH7.2] to Collagen VII
Research Area Extracellular Matrix
Application Notes Dot: Use at an assay dependant dilution. ELISA: Use at an assay dependant dilution. ICC: Use at an assay dependant dilution. IF: Use at a dilution of 1/1000. (human or other mammalian frozen sections)IHC-Fr: Use at an assay dependant dilution. WB: Use at an assay dependant dilution. Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user.
Restrictions For Research Use only
Format Liquid
Buffer Ascites fluid
Preservative Sodium azide
Wetzels, Robben, Leigh et al.: "Distribution patterns of type VII collagen in normal and malignant human tissues." in: The American journal of pathology, Vol. 139, Issue 2, pp. 451-9, 1991 (PubMed).

Fine, Horiguchi, Stein et al.: "Intraepidermal type VII collagen. Evidence for abnormal intracytoplasmic processing of a major basement membrane protein in rare patients with dominant and possibly localized recessive forms of dystrophic epidermolysis bullosa." in: Journal of the American Academy of Dermatology, Vol. 22, Issue 2 Pt 1, pp. 188-95, 1990 (PubMed).

Sanes, Engvall, Butkowski et al.: "Molecular heterogeneity of basal laminae: isoforms of laminin and collagen IV at the neuromuscular junction and elsewhere." in: The Journal of cell biology, Vol. 111, Issue 4, pp. 1685-99, 1990 (PubMed).

Shimizu, McDonald, Gunner et al.: "Epidermolysis bullosa acquisita antigen and the carboxy terminus of type VII collagen have a common immunolocalization to anchoring fibrils and lamina densa of basement membrane." in: The British journal of dermatology, Vol. 122, Issue 5, pp. 577-85, 1990 (PubMed).

Wetzels, Holland, van Haelst et al.: "Detection of basement membrane components and basal cell keratin 14 in noninvasive and invasive carcinomas of the breast." in: The American journal of pathology, Vol. 134, Issue 3, pp. 571-9, 1989 (PubMed).

Kirkham, Price, Gibson et al.: "Type VII collagen antibody LH 7.2 identifies basement membrane characteristics of thin malignant melanomas." in: The Journal of pathology, Vol. 157, Issue 3, pp. 243-7, 1989 (PubMed).

Heagerty, Kennedy, Leigh et al.: "Identification of an epidermal basement membrane defect in recessive forms of dystrophic epidermolysis bullosa by LH 7:2 monoclonal antibody: use in diagnosis." in: The British journal of dermatology, Vol. 115, Issue 2, pp. 125-31, 1986 (PubMed).

Alternatives for antigen "Collagen, Type VII (COL7)", type "Antibodies"
Hosts (24), (14), (5)
Reactivities (24), (14), (3), (3), (2), (2), (2), (2), (2), (2), (1), (1)
Applications (22), (18), (18), (17), (16), (14), (6), (5), (3), (2), (1), (1), (1)
Conjugates (2)
Epitopes (10), (7), (4), (3), (1)