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TNFSF11 antibody (Tumor Necrosis Factor (Ligand) Superfamily, Member 11) (AA 1-317)

Details for Product anti-TNFSF11 Antibody No. ABIN146331, Supplier: Login to see New
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Synonyms TNFSF11, BTF3L1, HUMBTFB, OCIF, OPG, TNFRSF11B, CD254, ODF, OPGL, OPTB2, RANKL, TRANCE, hRANKL2, sOdf, Ly109l, Trance, Opg
AA 1-317
(14), (14), (13), (13), (11), (10), (9), (4), (4), (4), (4), (4), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Mouse (Murine)
(177), (126), (41), (1), (1), (1), (1)
(172), (48), (33), (11), (1)
Clonality (Clone)
Monoclonal ()
This TNFSF11 antibody is un-conjugated
(31), (13), (6), (6), (5), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Immunohistochemistry (IHC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(188), (115), (51), (44), (33), (22), (22), (16), (13), (12), (12), (5), (5), (4), (1), (1), (1), (1), (1)
Pubmed 4 references available
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Quantity 0.1 mg
Shipping to United States ( )
Immunogen Fusion protein, corresponding to amino acids 1-317 of Mouse sRANKL.
Clone 12A668
Isotype IgG1
Cross-Reactivity Human
Characteristics Cellular Localization: Cell Membrane and Secreted
Purification Protein G purified.
Alternative Name CD254 / RANKL (TNFSF11 Antibody Abstract)
Background SRANKL is a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis.
Synonyms: RANKL, Tnfsf11, Ly109l, sRANKL, ODF, OPGL, 21943, Trance, OPG
Pathways NF-kappaB Signaling
Application Notes IHC: Use at an assay dependent dilution. WB: Use at a concentration of 1-2 ug/ml. Detects a band of approximately 35 kDa. Is unsuitable for FACS. Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user.
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer Preservative: 0.02% Sodium Azide, Constituents: PBS
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid freeze-thaw cycles.
Storage 4 °C
Storage Comment Keep as concentrated solution. Store at 4°C short term. For extended storage aliquot and store at -20°C or below.
Supplier Images
Image no. 1 for anti-TNFSF11 antibody (Tumor Necrosis Factor (Ligand) Superfamily, Member 11) (AA 1-317) (ABIN146331) anti-Tumor Necrosis Factor (Ligand) Superfamily, Member 11 (TNFSF11) (AA 1-317) antibody
Background publications Fiumara, Snell, Li et al.: "Functional expression of receptor activator of nuclear factor kappaB in Hodgkin disease cell lines." in: Blood, Vol. 98, Issue 9, pp. 2784-90, 2001 (PubMed).

Pearse, Sordillo, Yaccoby et al.: "Multiple myeloma disrupts the TRANCE/ osteoprotegerin cytokine axis to trigger bone destruction and promote tumor progression." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 98, Issue 20, pp. 11581-6, 2001 (PubMed).

Kikuchi, Matsuguchi, Tsuboi et al.: "Gene expression of osteoclast differentiation factor is induced by lipopolysaccharide in mouse osteoblasts via Toll-like receptors." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 166, Issue 5, pp. 3574-9, 2001 (PubMed).

Hsu, Lacey, Dunstan et al.: "Tumor necrosis factor receptor family member RANK mediates osteoclast differentiation and activation induced by osteoprotegerin ligand." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 96, Issue 7, pp. 3540-5, 1999 (PubMed).

Catalog No. ABIN146331
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