Tumor Necrosis Factor (Ligand) Superfamily, Member 11 (TNFSF11) (AA 1-317) antibody

Details for Product No. ABIN146331
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Antigen
Synonyms TNFSF11, BTF3L1, HUMBTFB, OCIF, OPG, TNFRSF11B, CD254, ODF, OPGL, OPTB2, RANKL, TRANCE, hRANKL2, sOdf, Ly109l, Trance, Opg
Epitope
AA 1-317
(10), (8), (5), (4), (3), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Mouse (Murine)
(117), (99), (32), (25), (13), (1), (1)
Host
Mouse
(122), (24), (21), (7), (1)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(23), (8), (4), (4), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1)
Application
Immunohistochemistry (IHC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(130), (81), (34), (26), (23), (20), (16), (12), (10), (7), (5), (3), (3), (2), (2), (1)
Pubmed 4 references available
Quantity 0.1 mg
Shipping to United States (Change)
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Catalog No. ABIN146331
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Immunogen Fusion protein, corresponding to amino acids 1-317 of Mouse sRANKL.
Clone 12A668
Isotype IgG1
Cross-Reactivity Human
Characteristics Cellular Localization: Cell Membrane and Secreted
Purification Protein G purified.
Alternative Name CD254 / RANKL
Background SRANKL is a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis.
Synonyms: RANKL, Tnfsf11, Ly109l, sRANKL, ODF, OPGL, 21943, Trance, OPG
Application Notes IHC: Use at an assay dependent dilution. WB: Use at a concentration of 1-2 ug/ml. Detects a band of approximately 35 kDa. Is unsuitable for FACS. Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user.
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer Preservative: 0.02% Sodium Azide, Constituents: PBS
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid freeze-thaw cycles.
Storage 4 °C
Storage Comment Keep as concentrated solution. Store at 4°C short term. For extended storage aliquot and store at -20°C or below.
Supplier Images
anti-Tumor Necrosis Factor (Ligand) Superfamily, Member 11 (TNFSF11) (AA 1-317) antibody anti-Tumor Necrosis Factor (Ligand) Superfamily, Member 11 (TNFSF11) (AA 1-317) antibody
General Hsu, Lacey, Dunstan et al.: "Tumor necrosis factor receptor family member RANK mediates osteoclast differentiation and activation induced by osteoprotegerin ligand." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 96, Issue 7, pp. 3540-5, 1999 (PubMed).

Kikuchi, Matsuguchi, Tsuboi et al.: "Gene expression of osteoclast differentiation factor is induced by lipopolysaccharide in mouse osteoblasts via Toll-like receptors." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 166, Issue 5, pp. 3574-9, 2001 (PubMed).

Pearse, Sordillo, Yaccoby et al.: "Multiple myeloma disrupts the TRANCE/ osteoprotegerin cytokine axis to trigger bone destruction and promote tumor progression." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 98, Issue 20, pp. 11581-6, 2001 (PubMed).

Fiumara, Snell, Li et al.: "Functional expression of receptor activator of nuclear factor kappaB in Hodgkin disease cell lines." in: Blood, Vol. 98, Issue 9, pp. 2784-90, 2001 (PubMed).

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