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Details for Product No. ABIN146331

Tumor Necrosis Factor (Ligand) Superfamily, Member 11 (TNFSF11) antibody

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Antigen
Synonyms ODF, OPGL, sOdf, CD254, OPTB2, RANKL, TRANCE, hRANKL2, Ly109l, OPG, Trance, TNFSF11
Reactivity
»Alternatives Mouse (Murine)
Host
»Alternatives Mouse
Clonality Monoclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB), Immunohistochemistry (IHC)
Pubmed 4 references available
Catalog no. ABIN146331
Quantity 0.1 mg
Price
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Immunogen Fusion protein, corresponding to amino acids 1-317 of Mouse sRANKL.
Isotype IgG1
Purification Protein G affinity purified
Alternative Name CD254 / RANKL
Background SRANKL is a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis.
Application Notes IHC: Use at an assay dependent dilution. WB: Use at a concentration of 1-2 ug/ml. Detects a band of approximately 35 kDa. Is unsuitable for FACS. Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user.
Restrictions For Research Use only
Concentration 0.5 mg/ml
Buffer PBS
Preservative Sodium azide
Storage 4 °C
Hsu, Lacey, Dunstan et al.: "Tumor necrosis factor receptor family member RANK mediates osteoclast differentiation and activation induced by osteoprotegerin ligand." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 96, Issue 7, pp. 3540-5, 1999 (PubMed).

Kikuchi, Matsuguchi, Tsuboi et al.: "Gene expression of osteoclast differentiation factor is induced by lipopolysaccharide in mouse osteoblasts via Toll-like receptors." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 166, Issue 5, pp. 3574-9, 2001 (PubMed).

Pearse, Sordillo, Yaccoby et al.: "Multiple myeloma disrupts the TRANCE/ osteoprotegerin cytokine axis to trigger bone destruction and promote tumor progression." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 98, Issue 20, pp. 11581-6, 2001 (PubMed).

Fiumara, Snell, Li et al.: "Functional expression of receptor activator of nuclear factor kappaB in Hodgkin disease cell lines." in: Blood, Vol. 98, Issue 9, pp. 2784-90, 2001 (PubMed).

Alternatives for antigen "Tumor Necrosis Factor (Ligand) Superfamily, Member 11 (TNFSF11)", type "Antibodies"
Hosts (99), (26), (22), (11)
Reactivities (115), (96), (30), (25), (15), (1)
Applications (120), (75), (42), (25), (20), (17), (9), (8), (5), (4), (4), (3), (2), (2), (2), (2), (2), (1)
Conjugates (25), (8), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2)
Epitopes (14), (8), (8), (4), (3), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
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