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Secreted phosphoprotein 1 (SPP1) antibody
| Antigen | Secreted phosphoprotein 1 (SPP1) |
| Synonyms | OPN, BNSP, BSPI, ETA-1, MGC110940, OP, Bsp, Eta, Opn, Ric, Opnl, Apl-1, Spp-1, AA960535, AI790405, OSP, SPP1, spp1, MGC111821 |
| Clonality | Polyclonal |
| Host |
 Alternatives Rabbit |
| Reactivity |
Alternatives Human |
| Application |
Alternatives Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
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| Catalog no. | ABIN146683 |
| Quantity | 7 ml (Variants) |
| Price | Product not available in this region. |
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Additional Information
| Alternative name | Osteopontin / SPP1 |
| Immunogen | A synthetic peptide derived from internal domain of human Osteopontin. |
| Isotype | IgG (Matching secondary antibodies) |
| Description | Osteopontin is an arginine-glycine-aspartic acid (RGD)-containing glycoprotein that interacts with integrins and CD44 as major receptors. OPN is multifunctional, with activities in cell migration, cell survival, inhibition of calcification, regulation of immune cell function, and control of tumor cell phenotype. Targeting of the gene encoding Osteopontin, has revealed that while it is not necessary for normal embryonic development, fertility, and health under pathogen-free conditions, loss of the protein has significant consequences in several models of injury/disease as diverse as renal injury, viral and bacterial infection, bone remodeling, and tumor growth. The fact that no other proteins seem to share a redundant activity with Osteopontin under these conditions suggests that it has a unique functional role during tissue injury and stress. |
Application Details
| Application Notes | IHC-P: Use at an assay dependent dilution. Staining of formalin-fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0 for 10 min followed by cooling at RT for 20 min. Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user. |
| Purity | Immunogen affinity purified |
| Buffer | Preservative: Sodium AzideConstituents: PBS, BSA |
| Storage | Store at 4C. Aliquot and store at -20C long-term. |
| Research Area | Hormones, Enzymes, Metabolism, Extracellular Matrix |
| Restrictions | For Research Use only |
Alternatives
Alternatives for antigen "Secreted phosphoprotein 1 (SPP1)", type "Antibodies"
| Hosts | Rabbit (50), Mouse (45), Goat (7) |
| Reactivities | Human (75), Mouse (Murine) (29), Rat (Rattus) (25), Dog (Canine) (8), Pig (Porcine) (4) |
| Applications | Western Blotting (WB) (83), Enzyme Immunoassay (EIA) (48), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (22), ELISA (19), Flow Cytometry (FACS) (14), Immunofluorescence (IF) (13), Immunohistochemistry (IHC) (11), Immunocytochemistry (ICC) (2), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (2), Immunohistochemistry (Frozen Sections) (IHC (fro)) (2), Immunoprecipitation (IP) (2), ELISA (Detection) (1), Immunoelectron Microscopy (IEM) (1) |
| Conjugates | Alexa Flour 488 (1), Biotin (1), Cy3 (1), Cy5 (1), Cy5.5 (1), Cy7 (1), FITC (1), Gold (1), HRP (1), PE (1), PE,Cy3 (1), PE,Cy5 (1), PE,Cy7 (1), RBITC (1) |
| Epitopes | C-Term (7), AA 164-179 (5), AA 59-74 (5), N-Term (5), AA 0-17 (3) |
