anti-osteopontin (SPP1) antibody

Overview

» Click the image to enlarge
	Antigen:	Osteopontin (SPP1)
	Clonality:	Polyclonal
	Application:	Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
	Reactivity:	Human, Dog (Canine)
	Host:	Rabbit
	Quantity:	7 ml (Product variants)
	Price:	Product not available in this region.
	Order number:	ABIN146683
	Did you already select your shipping region? Select your region:

Antigen	Osteopontin (SPP1)
Immunogen	A synthetic peptide derived from internal domain of human Osteopontin.
Reactivity	Human, Dog (Canine)
Clonality	Polyclonal
Format	Liquid
Isotype	IgG »Matching secondary antibodies
Description	Osteopontin is an arginine-glycine-aspartic acid (RGD)-containing glycoprotein that interacts with integrins and CD44 as major receptors. OPN is multifunctional, with activities in cell migration, cell survival, inhibition of calcification, regulation of immune cell function, and control of tumor cell phenotype. Targeting of the gene encoding Osteopontin, has revealed that while it is not necessary for normal embryonic development, fertility, and health under pathogen-free conditions, loss of the protein has significant consequences in several models of injury/disease as diverse as renal injury, viral and bacterial infection, bone remodeling, and tumor growth. The fact that no other proteins seem to share a redundant activity with Osteopontin under these conditions suggests that it has a unique functional role during tissue injury and stress.
Host	Rabbit

Application	Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) » Click here to view 1 available protocol!
Application Notes	IHC-P: Use at an assay dependent dilution. Staining of formalin-fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0 for 10 min followed by cooling at RT for 20 min. Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user.
Purity	Immunogen affinity purified
Buffer	Preservative: Sodium AzideConstituents: PBS, BSA
Storage	Store at 4C. Aliquot and store at -20C long-term.
Restrictions	For Research Use only