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Details for Product No. ABIN147064

FXYD Domain Containing Ion Transport Regulator 5 (FXYD5) antibody

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Synonyms DYSAD, IWU1, KCT1, OIT2, PRO6241, RIC, EF-8, Oit2, FXYD5
»Alternatives Human
Clonality Polyclonal
»Alternatives Western Blotting (WB)
Pubmed 1 reference available
Catalog no. ABIN147064
Quantity 50 µg
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Immunogen Synthetic peptide: GKCRQLSRLCRNHCR (Human).
Isotype IgG
Purification Ig Fraction
Alternative Name Dysadherin / FXYD5
Background This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Mouse FXYD5 has been termed RIC (Related to Ion Channel). FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane.
Application Notes Western Blot-Approx 40kDa band seen in Jurkat lysate. Recommended for use at 0.5-1.5ug/ml. Note that the protein is a glycoprotein and is known to migrate at a higher than expected size (Proc Natl Acad Sci U S A 2002 Jan 8,99(1):365-70).
Restrictions For Research Use only
Concentration 0.5 mg/ml
Buffer Tris saline, 0.02% Na azide, pH7.3 with 0.5% BSA
Preservative Sodium azide
Storage -20 °C
Ino, Gotoh, Sakamoto et al.: "Dysadherin, a cancer-associated cell membrane glycoprotein, down-regulates E-cadherin and promotes metastasis." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 1, pp. 365-70, 2002 (PubMed).

Alternatives for antigen "FXYD Domain Containing Ion Transport Regulator 5 (FXYD5)", type "Antibodies"
Hosts (16), (7)
Reactivities (20)
Applications (21), (6), (5), (3)
Epitopes (4), (3), (3), (2), (2), (2), (1)