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FXYD Domain Containing Ion Transport Regulator 5 (FXYD5) antibody

Details for Product No. ABIN147064, Supplier: Login to see
Antigen
  • FXYD5
  • DYSAD
  • IWU1
  • KCT1
  • OIT2
  • PRO6241
  • RIC
  • EF-8
  • Oit2
Reactivity
Human
58
1
1
1
Host
Goat
42
16
Clonality
Polyclonal
Conjugate
Un-conjugated
3
3
3
3
3
3
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
48
32
20
8
1
Supplier
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Immunogen Synthetic peptide: GKCRQLSRLCRNHCR (Human).
Isotype IgG
Purification IgG fraction. Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide..
Alternative Name Dysadherin / FXYD5 (FXYD5 Antibody Abstract)
Background This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Mouse FXYD5 has been termed RIC (Related to Ion Channel). FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane.
Synonyms: dysad, Q96DB9, FXYD5, OIT2, PRO6241, Dysadherin, HSPC113, 606669, RIC, IWU1, KCT1, 53827, IWU-1, IWU 1
Pathways
Application Notes Western Blot-Approx 40kDa band seen in Jurkat lysate. Recommended for use at 0.5-1.5ug/ml. Note that the protein is a glycoprotein and is known to migrate at a higher than expected size (Proc Natl Acad Sci U S A 2002 Jan 8,99(1):365-70).
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer Tris saline, 0.02% Na azide, pH7.3 with 0.5% BSA
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid freeze-thaw cycles.
Storage -20 °C
Storage Comment Upon receipt - Keep as concentrated solution. Aliquot and store at -20°C or below.
Supplier Images
Immunohistochemistry (IHC) image for anti-FXYD Domain Containing Ion Transport Regulator 5 (FXYD5) antibody (ABIN147064) anti-FXYD Domain Containing Ion Transport Regulator 5 (FXYD5) antibody
Western Blotting (WB) image for anti-FXYD Domain Containing Ion Transport Regulator 5 (FXYD5) antibody (ABIN147064) anti-FXYD Domain Containing Ion Transport Regulator 5 (FXYD5) antibody (Image 2)
Western Blotting (WB) image for anti-FXYD Domain Containing Ion Transport Regulator 5 (FXYD5) antibody (ABIN147064) anti-FXYD Domain Containing Ion Transport Regulator 5 (FXYD5) antibody (Image 3)
Background publications Ino, Gotoh, Sakamoto et al.: "Dysadherin, a cancer-associated cell membrane glycoprotein, down-regulates E-cadherin and promotes metastasis." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 1, pp. 365-70, 2002 (PubMed).