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FXYD Domain Containing Ion Transport Regulator 5 (FXYD5) antibody

Details for Product No. ABIN147064
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Antigen
Synonyms DYSAD, IWU1, KCT1, OIT2, PRO6241, RIC, EF-8, Oit2, FXYD5
Reactivity
Human
(23)
Host
Goat
(20), (6)
Clonality
Polyclonal
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(24), (11), (8), (3)
Pubmed 1 reference available
Quantity 50 µg
Shipping to United States (Change)
Catalog No. ABIN147064
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  • +1 404 474 4654
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Immunogen Synthetic peptide: GKCRQLSRLCRNHCR (Human).
Isotype IgG
Purification Ig Fraction
Alternative Name Dysadherin / FXYD5
Background This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Mouse FXYD5 has been termed RIC (Related to Ion Channel). FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane.
Application Notes Western Blot-Approx 40kDa band seen in Jurkat lysate. Recommended for use at 0.5-1.5ug/ml. Note that the protein is a glycoprotein and is known to migrate at a higher than expected size (Proc Natl Acad Sci U S A 2002 Jan 8,99(1):365-70).
Restrictions For Research Use only
Concentration 0.5 mg/ml
Buffer Tris saline, 0.02% Na azide, pH7.3 with 0.5% BSA
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
General Ino, Gotoh, Sakamoto et al.: "Dysadherin, a cancer-associated cell membrane glycoprotein, down-regulates E-cadherin and promotes metastasis." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 1, pp. 365-70, 2002 (PubMed).

Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN147064
Contact our Customer Service for availability and price in your country.
Add to Basket

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
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