Claspin (CLSPN) antibody

Details for Product No. ABIN147203
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Antigen
Synonyms CLSPN, xClaspin, B130025E01, C85083, E130314M08Rik
Reactivity
Human
(16), (1), (1)
Host
Rabbit
(16)
Clonality
Polyclonal
Application
Immunoprecipitation (IP), Western Blotting (WB)
(16), (9), (2), (1), (1), (1)
Pubmed 1 reference available
Quantity 50 μL
Shipping to United States (Change)
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Catalog No. ABIN147203
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Immunogen Synthetic peptide (Human) - which represents a portion of human Claspin encoded within exon 15.
Isotype IgG
Purification Immunogen affinity purified.
Alternative Name Claspin
Background The product of this gene is an essential upstream regulator of checkpoint kinase 1 and triggers a checkpoint arrest of the cell cycle in response to replicative stress or DNA damage. The protein is also required for efficient DNA replication during a normal S phase. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]
Synonyms: 63967, CLASPIN, CLSPN, 605434, Q9HAW4
Research Area Chromatin and Nuclear Signaling, Cell Cycle, DNA/RNA
Application Notes IP: Use at a concentration of 1-5 ug/ml. WB: Use at a dilution of 1/1000-1/10000. Predicted molecular weight: 180 kDa. Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user.
Comment

Positive Controls: HeLa cell lysate

Restrictions For Research Use only
Format Liquid
Concentration 1 mg/mL
Buffer Tris-citrate/phosphate, pH 7-8, 0.1% sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Do not freeze
Storage 4 °C
Storage Comment Keep as concentrated solution, aliquot and store at 4°C.
General Jiang, Pereira, Maxfield et al.: "Regulation of Chk1 includes chromatin association and 14-3-3 binding following phosphorylation on Ser-345." in: The Journal of biological chemistry, Vol. 278, Issue 27, pp. 25207-17, 2003 (PubMed).

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