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Ubiquitin Protein Ligase E3 Component N-Recognin 5 (UBR5) (C-Term) antibody

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Synonyms DD5, EDD, EDD1, HYD, 4432411E13Rik, AW549941, C77315, D030042K14, Edd, Edd1, mKIAA0896, Dd5, Rat100
(32), (8), (4), (3), (1), (1), (1), (1), (1), (1), (1), (1), (1)
(78), (35), (20), (7), (6), (4), (2), (2), (1), (1)
(55), (20), (3), (1)
(4), (4), (4), (3), (3), (3), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(44), (41), (39), (15), (11), (6), (3), (2)
Pubmed 1 reference available
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Quantity 0.1 mg
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Immunogen Synthetic peptide: LAIKTKNFGFV from C Terminus of the protein sequence according to NP_056986.
Isotype IgG
Cross-Reactivity Mouse (Murine), Rat (Rattus)
Purification IgG fraction. Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide..
Alternative Name UBR5 / HYD (UBR5 Antibody Abstract)
Background This is a progestin-induced protein, which belongs to the HECT (homology to E6-AP carboxyl terminus) family. The HECT family proteins function as E3 ubiquitin-protein ligases, targeting specific proteins for ubiquitin-mediated proteolysis. This gene is localized to chromosome 8q22, a locus disrupted in a variety of cancers. This gene potentially has a role in regulation of cell proliferation or differentiation.
Synonyms: DD5, O95071, MGC57263, HYD, 51366, EDD1, KIAA0896, EDD, 608413, FLJ11310
Application Notes ELISA: peptide ELISA (antibody detection limit dilution >1 / 32000). WB: Approx. 35-40 kDa band observed in Human Testis, Human Muscle, A549 and A431 lysates at 0.5-1ug of primary. Please note that the band we observe is different from the predicted size of approx. 322 kDa according to NP_056986 (furthermore, our SDS PAGE/western blotting protocol is not optimized for detection of proteins as large as the predicted). Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user.
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer Tris saline, 0.02% Na azide, pH7.3 with 0.5% BSA
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid freeze-thaw cycles.
Storage -20 °C
Storage Comment Upon receipt - Keep as concentrated solution. Aliquot and store at -20°C or below.
Supplier Images
Image no. 1 for anti-Ubiquitin Protein Ligase E3 Component N-Recognin 5 (UBR5) (C-Term) antibody (ABIN147445) anti-Ubiquitin Protein Ligase E3 Component N-Recognin 5 (UBR5) (C-Term) antibody
Background publications Callaghan, Russell, Woollatt et al.: "Identification of a human HECT family protein with homology to the Drosophila tumor suppressor gene hyperplastic discs." in: Oncogene, Vol. 17, Issue 26, pp. 3479-91, 1999 (PubMed).

Catalog No. ABIN147445
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