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Details for Product No. ABIN147445

Ubiquitin Protein Ligase E3 Component N-Recognin 5 (UBR5) antibody

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Antigen
Synonyms DD5, EDD, EDD1, HYD, 4432411E13Rik, AW549941, C77315, D030042K14, Edd, Edd1, mKIAA0896, Dd5, Rat100
Reactivity
»Alternatives Human
Host
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives ELISA, Western Blotting (WB)
Pubmed 1 reference available
Catalog no. ABIN147445
Quantity 0.1 mg
Price
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Immunogen Synthetic peptide: LAIKTKNFGFV from C Terminus of the protein sequence according to NP_056986.
Isotype IgG
Cross-Reactivity Mouse (Murine), Rat (Rattus)
Purification Purified IgG fraction
Alternative Name UBR5 / HYD
Background This is a progestin-induced protein, which belongs to the HECT (homology to E6-AP carboxyl terminus) family. The HECT family proteins function as E3 ubiquitin-protein ligases, targeting specific proteins for ubiquitin-mediated proteolysis. This gene is localized to chromosome 8q22, a locus disrupted in a variety of cancers. This gene potentially has a role in regulation of cell proliferation or differentiation.
Application Notes ELISA: peptide ELISA (antibody detection limit dilution >1 / 32000). WB: Approx. 35-40 kDa band observed in Human Testis, Human Muscle, A549 and A431 lysates at 0.5-1ug of primary. Please note that the band we observe is different from the predicted size of approx. 322 kDa according to NP_056986 (furthermore, our SDS PAGE/western blotting protocol is not optimized for detection of proteins as large as the predicted). Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user.
Restrictions For Research Use only
Concentration 0.5 mg/ml
Buffer Tris saline, 0.02% Na azide, pH7.3 with 0.5% BSA
Preservative Sodium azide
Storage -20 °C
Callaghan, Russell, Woollatt et al.: "Identification of a human HECT family protein with homology to the Drosophila tumor suppressor gene hyperplastic discs." in: Oncogene, Vol. 17, Issue 26, pp. 3479-91, 1999 (PubMed).

Alternatives for antigen "Ubiquitin Protein Ligase E3 Component N-Recognin 5 (UBR5)", type "Antibodies"
Hosts (33), (8), (1), (1)
Reactivities (43), (32), (16), (15), (12), (12), (3), (2)
Applications (25), (24), (17), (12), (10), (3), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (9), (5), (1), (1), (1), (1), (1)
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