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Inhibitor of Growth Family, Member 2 (ING2) (C-Term) antibody

Details for Product No. ABIN147814, Supplier: Login to see
Antigen
  • ING2
  • INGX
  • ING1L
  • p33ING2
  • 2810011M06Rik
  • Ing1l
  • Ing2b
  • P33ING2
Epitope
C-Term
15
14
13
11
5
3
2
2
2
1
1
1
Reactivity
Human
69
9
9
3
1
1
1
Host
Goat
37
16
16
Clonality
Polyclonal
Conjugate
Un-conjugated
3
3
3
3
3
3
Application
Immunocytochemistry (ICC), Immunofluorescence (IF), Western Blotting (WB)
59
43
11
5
2
1
1
Supplier
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Immunogen Peptide with sequence DKSTEKTKKDRRSR, from C Terminus of the protein sequence according to NP_001555
Isotype IgG
Purification IgG fraction. Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide..
Alternative Name ING2 / ING1L (ING2 Antibody Abstract)
Background This protein is similar to ING1, a tumor suppressor protein that can bind TP53, inhibit cell growth, and induce apoptosis. This protein binds phosphoinositides (PtdInPs) at its plant homeodomain (PHD) domain and it acts as a PtdInPs receptor. PtdInPs binding regulates the ability of this protein to activate TP53 and TP53-dependent apoptosis.
Synonyms: ING1L, p33ING2
Pathways
Application Notes IF: Use at an assay dependent dilution. WB: Use at a concentration of 2-4 ug/ml. Detects a band of approximately 33 kDa (predicted molecular weight: 32.8 kDa). Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user.
Comment

Positive Controls: HepG2 lysate

Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer Tris saline, 0.02% Na azide, pH7.3 with 0.5% BSA
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid freeze-thaw cycles.
Storage -20 °C
Storage Comment Upon receipt - Keep as concentrated solution. Aliquot and store at -20°C or below.
Supplier Images
Western Blotting (WB) image for anti-Inhibitor of Growth Family, Member 2 (ING2) (C-Term) antibody (ABIN147814) anti-Inhibitor of Growth Family, Member 2 (ING2) (C-Term) antibody
Background publications Shimada, Saito, Suzuki et al.: "Cloning of a novel gene (ING1L) homologous to ING1, a candidate tumor suppressor." in: Cytogenetics and cell genetics, Vol. 83, Issue 3-4, pp. 232-5, 1999 (PubMed).