Inhibitor of Growth Family, Member 2 (ING2) antibody

Antigen: Inhibitor of Growth Family, Member 2 (ING2)

Synonyms: ING1L, p33ING2, Ing1l, Ing2b, P33ING2, 2810011M06Rik, ING2, INGX

Clonality: Polyclonal

Host: Goat

Reactivity: Human

Application: Immunofluorescence (IF), Western Blotting (WB)

Catalog no.: ABIN147814

Additional Information

Alternative name: ING2 / ING1L

Immunogen: Peptide with sequence DKSTEKTKKDRRSR, from C Terminus of the protein sequence according to NP_001555

Cross-Reactivity: Human

Isotype: IgG

Description: This protein is similar to ING1, a tumor suppressor protein that can bind TP53, inhibit cell growth, and induce apoptosis. This protein binds phosphoinositides (PtdInPs) at its plant homeodomain (PHD) domain and it acts as a PtdInPs receptor. PtdInPs binding regulates the ability of this protein to activate TP53 and TP53-dependent apoptosis.

Application Details

Application Notes: IF: Use at an assay dependent dilution. WB: Use at a concentration of 2-4 ug/ml. Detects a band of approximately 33 kDa (predicted molecular weight: 32.8 kDa). Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user.

Concentration: 0.5 mg/ml

Purification: Ig Fraction

Buffer: Tris saline, 0.02% Na azide, pH7.3 with 0.5% BSA

Storage: Aliquot and store at -20 C. Minimize freezing and thawing.

Restrictions: For Research Use only

Publications

Shimada, Saito, Suzuki et al.: "Cloning of a novel gene (ING1L) homologous to ING1, a candidate tumor suppressor." in: Cytogenetics and cell genetics, Vol. 83, Issue 3-4, pp. 232-5, 1999 (PubMed).