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Claspin antibody (CLSPN)

Details for Product anti-CLSPN Antibody No. ABIN147835, Supplier: Login to see
Antigen
  • CLSPN
  • xClaspin
  • B130025E01
  • C85083
  • E130314M08Rik
Reactivity
Human
16
1
1
Host
Rabbit
16
Clonality
Polyclonal
Application
Western Blotting (WB)
16
8
2
1
1
1
Supplier
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Immunogen Synthetic peptide (Human) - which represented a portion of human Claspin encoded within exon 8.
Isotype IgG
Purification Immunogen affinity purified.
Alternative Name Claspin (CLSPN Antibody Abstract)
Background The product of this gene is an essential upstream regulator of checkpoint kinase 1 and triggers a checkpoint arrest of the cell cycle in response to replicative stress or DNA damage. The protein is also required for efficient DNA replication during a normal S phase. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]
Synonyms: 63967, CLASPIN, CLSPN, 605434, Q9HAW4
Research Area Chromatin and Nuclear Signaling, Cell Cycle, DNA/RNA
Pathways
Application Notes WB: Use at a dilution of 1/1000-1/5000. Predicted molecular weight: 180 kDa. Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user.
Comment

Positive Controls: HeLa cell lysate

Restrictions For Research Use only
Format Liquid
Concentration 1 mg/mL
Buffer Tris-citrate/phosphate, pH 7-8, 0.1% sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Do not freeze
Storage 4 °C
Storage Comment Keep as concentrated solution, aliquot and store at 4°C.
Background publications Jiang, Pereira, Maxfield et al.: "Regulation of Chk1 includes chromatin association and 14-3-3 binding following phosphorylation on Ser-345." in: The Journal of biological chemistry, Vol. 278, Issue 27, pp. 25207-17, 2003 (PubMed).