DOK1 (Human) antibody

Overview

Antigen	DOK1
Immunogen	This antibody was developed against a synthetic peptide containing amino acids 425-439 (PQGPAFPEPGTATGS) of human p62dok.
Reactivity	Human
Antibody Type	Polyclonal
Format	Liquid
Isotype	IgG »Matching secondary antibodies
Description	P62dok is a major substrate for many tyrosine kinases including c-kit, v-abl, vFPS, EGF, and PDGF. Upon phosphorylation by kinases, p62dok forms a complex with ras GTPase-activating protein. Docking protein 1 is constitutively tyrosine phosphorylated in hematopoietic progenitors isolated from chronic myelogenous leukemia (CML) patients in the chronic phase. It may be a critical substrate for p210(bcr/abl), a chimeric protein whose presence is associated with CML. Docking protein 1 contains a putative pleckstrin homology domain at the amino terminus and ten PXXP SH3 recognition motifs. Docking protein 2 binds p120 (RasGAP) from CML cells. It has been postulated to play a role in mitogenic signaling.
Host	Rabbit

Application	Western Blotting (WB)
Application Notes	WB: Use at a concentration of 1-2 ug/ml. Detects a band of approximately 62 kDa (predicted molecular weight: 58 kDa). Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user.
Concentration	0.5 mg/ml
Purity	Protein G purified
Buffer	Preservative: 0.02% Sodium AzideConstituents: PBS.
Storage	Store at 4 C. Aliquot and store at -20 C long-term.
Restrictions	For research use only

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