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Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 5 (RPS6KA5) (pThr581) antibody

Details for Product No. ABIN148003
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Antigen
Synonyms MSK1, MSPK1, RLPK, 3110005L17Rik, 6330404E13Rik, AI854034, Msk1
Epitope
pThr581
(25), (22), (22), (18), (12), (6), (4), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(173), (132), (60), (60), (59), (48), (48)
Host
Rabbit
(167), (5), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(6), (6), (6), (5), (5), (5), (5), (5), (5), (5), (5), (1), (1), (1)
Application
Western Blotting (WB)
(111), (83), (50), (40), (29), (29), (10), (2), (2), (1)
Pubmed 2 references available
Quantity 50 µg
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Catalog No. ABIN148003
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  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen Available on request.
Isotype IgG
Specificity This antibody detects 90 kDa MSK 1 only when phosphorylated at Thr581. It does not cross-react with non-phosphorylated MSK 1, or MSK 1 phosphorylated at other sites. It does not cross-react with RSK 1, RSK 2 or RSK 3.
Cross-Reactivity Mouse (Murine)
Purification Immunogen affinity purified
Alternative Name RPS6KA5 / MSK1
Background MSK 1, a Mitogen and Stress activated protein Kinase, is activated by ERK as well as p38 MAPK in response to growth factors and various cellular stress stimuli. MSK 1 resembles RSK by having two kinase domains connected by a regulator linker region. Phosphorylation of RSK 1 at Ser 364, Ser381 and Thr574 is critical for RSK 1 activity. These sites are analogous to Ser360, Ser376 and Thr581 of MSK 1 and maybe important for MSK 1 activity as well.
Application Notes WB: Use at a concentration of 1-2 ug/ml. Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user.
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/ml
Buffer PBS pH 7.2 with 50% glycerol
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
General Ardenne, Reitnauer: "[Tumour hyperacidulation through intravenous glucose infusion enhanced by amygdalin and beta-glucosidase application (author's transl)]" in: Archiv für Geschwulstforschung, Vol. 45, Issue 2, pp. 135-45, 1976 (PubMed).

Deak, Clifton, Lucocq et al.: "Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB." in: The EMBO journal, Vol. 17, Issue 15, pp. 4426-41, 1998 (PubMed).

Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN148003
Contact our Customer Service for availability and price in your country.
Add to Basket

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
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