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Ring Finger Protein 19A (RNF19A) (C-Term) antibody

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Synonyms RNF19, RNF19A, AA032313, Dorfin, Rnf19, UIP117, Ubce7ip2, XYbp
(15), (13), (11), (8), (3), (2), (2), (2), (1), (1), (1), (1), (1)
(53), (20), (14), (3), (3), (2), (1), (1)
(45), (5), (4)
(3), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
ELISA, Western Blotting (WB)
(36), (31), (15), (11), (5), (1)
Pubmed 1 reference available
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Quantity 0.1 mg
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Immunogen Peptide with sequence QTMELKVAIQTEI, from C Terminus of the protein sequence according to NP_056250.
Isotype IgG
Purification IgG fraction. Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide..
Alternative Name RNF19A / RNF19 (RNF19A Antibody Abstract)
Background The protein contains two RING-finger motifs and an IBR (in between RING fingers) motif. This protein is an E3 ubiquintin ligase that is localized in Lewy bodies (LBs), a characteristic neuronal inclusion in Parkinson's disease (PD) brains. This protein interacts with UBE2L3/UBCH7 and UBE2E2/UBCH8, but not other ubiquitin-conjugating enzymes. This protein is found to bind and ubiquitylate synphilin 1 (SNCAIP), which is a interacting protein of alpha synuclein in neurons, and a major component of LB. Alternatively spliced transcript variants encoding the same protein have been reported.
Synonyms: 607119, RNF19, DKFZp566B1346, DORfiN, Q9NV58, 25897
Application Notes ELISA: peptide ELISA (antibody detection limit dilution 1/16000). Western Blot: No signal obtained yet but low background observed in Human Muscle, Human Kidney, Human Liver, Human Heart and Human Brain lysates at up to 2.0 ug/ml.
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer Tris saline, 0.02% Na azide, pH7.3 with 0.5% BSA
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid freeze-thaw cycles.
Storage -20 °C
Storage Comment Upon receipt - Keep as concentrated solution. Aliquot and store at -20°C or below.
Background publications Gunther, Laithier, Brison: "A set of proteins interacting with transcription factor Sp1 identified in a two-hybrid screening." in: Molecular and cellular biochemistry, Vol. 210, Issue 1-2, pp. 131-42, 2000 (PubMed).

Catalog No. ABIN148176
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