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Ring Finger Protein 19A (RNF19A) (C-Term) antibody

Details for Product No. ABIN148176, Supplier: Login to see
Antigen
  • RNF19
  • RNF19A
  • AA032313
  • Dorfin
  • Rnf19
  • UIP117
  • Ubce7ip2
  • XYbp
Epitope
C-Term
15
13
11
8
3
2
2
2
1
1
1
1
1
Reactivity
Human
53
20
14
3
3
2
1
1
Host
Goat
45
5
4
Clonality
Polyclonal
Conjugate
Un-conjugated
3
3
3
2
2
2
1
1
1
1
1
1
1
1
1
Application
ELISA, Western Blotting (WB)
36
31
15
11
5
1
Supplier
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Immunogen Peptide with sequence QTMELKVAIQTEI, from C Terminus of the protein sequence according to NP_056250.
Isotype IgG
Purification IgG fraction. Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide..
Alternative Name RNF19A / RNF19 (RNF19A Antibody Abstract)
Background The protein contains two RING-finger motifs and an IBR (in between RING fingers) motif. This protein is an E3 ubiquintin ligase that is localized in Lewy bodies (LBs), a characteristic neuronal inclusion in Parkinson's disease (PD) brains. This protein interacts with UBE2L3/UBCH7 and UBE2E2/UBCH8, but not other ubiquitin-conjugating enzymes. This protein is found to bind and ubiquitylate synphilin 1 (SNCAIP), which is a interacting protein of alpha synuclein in neurons, and a major component of LB. Alternatively spliced transcript variants encoding the same protein have been reported.
Synonyms: 607119, RNF19, DKFZp566B1346, DORfiN, Q9NV58, 25897
Pathways
Application Notes ELISA: peptide ELISA (antibody detection limit dilution 1/16000). Western Blot: No signal obtained yet but low background observed in Human Muscle, Human Kidney, Human Liver, Human Heart and Human Brain lysates at up to 2.0 ug/ml.
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer Tris saline, 0.02% Na azide, pH7.3 with 0.5% BSA
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid freeze-thaw cycles.
Storage -20 °C
Storage Comment Upon receipt - Keep as concentrated solution. Aliquot and store at -20°C or below.
Background publications Gunther, Laithier, Brison: "A set of proteins interacting with transcription factor Sp1 identified in a two-hybrid screening." in: Molecular and cellular biochemistry, Vol. 210, Issue 1-2, pp. 131-42, 2000 (PubMed).