Ring Finger Protein 19A (RNF19A) antibody
| Antigen |
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| Synonyms |
RNF19, DORFIN, DKFZp566B1346 |
| Clonality |
Polyclonal |
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Host
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Reactivity
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Conjugate
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Alexa Fluor 350 (1), Alexa Fluor 488 (1), Alexa Fluor 555 (1), Alexa Fluor 647 (1), Biotin (1), Cy3 (1), Cy5 (1), Cy5.5 (1), Cy7 (1), FITC (1), Gold (1), HRP (1), PE (1), PE-Cy3 (1), PE-Cy5 (1), PE-Cy5.5 (1), PE-Cy7 (1)
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Application
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| Catalog no. |
ABIN148176 |
| Quantity |
0.1 mg (0.5 mg/ml) |
| Price |
Product not available in this region.
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| Shipping to |
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Alternative name
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RNF19A / RNF19
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Immunogen
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Peptide with sequence QTMELKVAIQTEI, from C Terminus of the protein sequence according to NP_056250.
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Cross-Reactivity
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Human
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Isotype
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IgG
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Description
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The protein contains two RING-finger motifs and an IBR (in between RING fingers) motif. This protein is an E3 ubiquintin ligase that is localized in Lewy bodies (LBs), a characteristic neuronal inclusion in Parkinsons disease (PD) brains. This protein interacts with UBE2L3/UBCH7 and UBE2E2/UBCH8, but not other ubiquitin-conjugating enzymes. This protein is found to bind and ubiquitylate synphilin 1 (SNCAIP), which is a interacting protein of alpha synuclein in neurons, and a major component of LB. Alternatively spliced transcript variants encoding the same protein have been reported.
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Application Notes
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ELISA: peptide ELISA (antibody detection limit dilution 1/16000). Western Blot: No signal obtained yet but low background observed in Human Muscle, Human Kidney, Human Liver, Human Heart and Human Brain lysates at up to 2.0 ug/ml.
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Concentration
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0.5 mg/ml
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Purification
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Purified IgG fraction
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Buffer
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Tris saline, 0.02% Na azide, pH7.3 with 0.5% BSA
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Storage
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Aliquot and store at -20 C. Minimize freezing and thawing.
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Restrictions
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For Research Use only
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Gunther, Laithier, Brison: "A set of proteins interacting with transcription factor Sp1 identified in a two-hybrid screening." in: Molecular and cellular biochemistry, Vol. 210, Issue 1-2, pp. 131-42, 2000 (PubMed).
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Alternatives for antigen "Ring Finger Protein 19A (RNF19A)", type "Antibodies"
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Hosts
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Rabbit (29), Goat (3)
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Reactivities
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Human (29), Mouse (Murine) (25), Cow (Bovine) (19), Dog (Canine) (19), Pig (Porcine) (19), Rat (Rattus) (19)
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Applications
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Immunofluorescence (IF) (15), ELISA (14), Western Blotting (WB) (14), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (3), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (3), Immunoelectron Microscopy (IEM) (1), Immunohistochemistry (IHC) (1)
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Conjugates
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Alexa Fluor 350 (1), Alexa Fluor 488 (1), Alexa Fluor 555 (1), Alexa Fluor 647 (1), Biotin (1), Cy3 (1), Cy5 (1), Cy5.5 (1), Cy7 (1), FITC (1), Gold (1), HRP (1), PE (1), PE-Cy3 (1), PE-Cy5 (1), PE-Cy5.5 (1), PE-Cy7 (1)
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Epitopes
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N-Term (7), C-Term (1), Center (1), Internal Region,AA 383-413 (1)
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Alternatives 
