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Details for Product No. ABIN148190

Mechanistic Target of Rapamycin (serine/threonine Kinase) (FRAP1) (pSer2448) antibody

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Antigen
Synonyms FRAP, FRAP1, FRAP2, RAFT1, RAPT1, 2610315D21Rik, AI327068, Frap1, flat, frap1, tor, wu:fc22h08
Epitope
»Alternatives pSer2448
Reactivity
»Alternatives Human
Host
»Alternatives Rabbit
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB)
Pubmed 2 references available
Catalog no. ABIN148190
Quantity 0.1 mg
Price
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Immunogen Synthetic peptide: KRSRTRTDpSYSAGQSVEI (Human).
Isotype IgG
Specificity Specific for phospho mTOR, giving a band at approx 250 kD.
Purification Immunogen affinity purified
Alternative Name MTOR / FRAP1
Background FKBP12-rapamycin associated protein (FRAP) is one of a family of proteins involved in cell cycle progression, DNA recombination, and DNA damage detection. In rat, it is a 245-kD protein (symbolized RAFT1) with significant homology to the Saccharomyces cerevisiae protein TOR1 and has been shown to associate with the immunophilin FKBP12 in a rapamycin-dependent fashion (1). The FKBP12-rapamycin complex is known to inhibit progression through the G1 cell cycle stage by interfering with mitogenic signaling pathways involved in G1 progression in several cell types, as well as in yeast (2). The binding of FRAP to FKBP12-rapamycin correlated with the ability of these ligands to inhibit cell cycle progression (2).
Application Notes Western blot: use at 1/1000This product has been assayed by ELISA against 0.1ug of the immunizing peptide. A 1/6000-1/29,000 dilution of the antibody is recommended. Optimal dilutions should be determined by the end user.
Restrictions For Research Use only
Concentration 1 mg/ml
Buffer 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
Preservative Sodium azide
Storage -20 °C
Neviackas, Kerstein: "Pancreatic enzyme response with an elemental diet." in: Surgery, gynecology & obstetrics, Vol. 142, Issue 1, pp. 71-4, 1976 (PubMed).

Sabatini, Erdjument-Bromage, Lui et al.: "RAFT1: a mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs." in: Cell, Vol. 78, Issue 1, pp. 35-43, 1994 (PubMed).

Alternatives for antigen "Mechanistic Target of Rapamycin (serine/threonine Kinase) (FRAP1)", type "Antibodies"
Hosts (240), (13), (1), (1)
Reactivities (243), (153), (147), (63), (36), (24), (5), (2), (1)
Applications (138), (86), (76), (54), (50), (35), (24), (22), (3), (3), (3), (2), (2), (1)
Conjugates (6), (6), (5), (5), (5), (5), (5), (5), (5), (5), (5), (2)
Epitopes (42), (19), (18), (12), (8), (7), (6), (6), (4), (4), (3), (3), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1)
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