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Chemokine (C-C Motif) Receptor 10 (CCR10) antibody

Antigen

Chemokine (C-C Motif) Receptor 10 (CCR10)
Synonyms DEZ, ChemR23, CHEMERINR, MGC126105, MGC126106, GPR2, Gpr2, Cmkbr9, MGC151420, Gpcr27, mcmklr1, zgc:91924, CMKLR1, CCR10, si:ch211-240b21.3, Cmklr-1, GPCR
Clonality Polyclonal
Host
Reactivity
Alternatives

Human
Conjugate
Alternatives Un-conjugated
Application
Alternatives Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB), ELISA
2 references available
Catalog no. ABIN148292
Quantity 0.1 mg  (2 mg/ml)  (Variants)
Price Product not available in this region.
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Additional Information
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Alternative name CCR10 / GPR2
Immunogen Synthetic peptide: VSWGHYSGDEEDAYSAEPLPELC, corresponding to amino acids 9-31 of Human CCR10.
Cross-Reactivity Human
Isotype IgG
Description Receptors for the C-C chemokine family include CCR-1, CCR-2A, CCR-3, CCR-4, CCR-5 and the Duffy blood group antigen. The C-C receptors are important in the function of T cell chemotaxis and migration of phagocytic cells to sites of inflammation. CCR10 in particular is the receptor for the skin-associated CC chemokine CCL27 (CTACK) as well as the novel chemokine CCL28 that displays chemotactic activity for resting CD4+ and CD8+ T cells.
Specificity Peptide sequence is < 50 % identical to other human chemokine receptors in this region.

Application Details
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Application Notes ELISA: Use at a dilution of 1/75000. ICC: Use at a dilution of 1/1000. IHC-P: Use at a dilution of 1/500. WB: Use at a dilution of 1/250. Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user.
Concentration 2 mg/ml
Purification Immunogen affinity purified
Buffer 10 mM KHPO4, 140 mM NaCl, pH 7.2 with 1 mg/ml BSA and 0.1 % sodium azide.
Storage Aliquot and store at -20 to -80 C
Research Area Chemokines, Receptors
Restrictions For Research Use only

Publications
Application Details Alternatives Variants back to top

Lefkowitz: "Identification of adenylate cyclase-coupled beta-adrenergic receptors with radiolabeled beta-adrenergic antagonists." in: Biochemical pharmacology, Vol. 24, Issue 18, pp. 1651-8, 1976 (PubMed).

Zaballos, Gutiuerrez, Varona et al.: "Cutting edge: identification of the orphan chemokine receptor GPR-9-6 as CCR9, the receptor for the chemokine TECK." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 162, Issue 10, pp. 5671-5, 1999 (PubMed).