Alstrom Syndrome 1 (ALMS1) (C-Term) antibody

Details for Product No. ABIN148489
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Antigen
Synonyms ALMS1, ALSS, bbb
Epitope
C-Term
(6), (6), (2), (1), (1)
Reactivity
Human
(19), (2), (2), (1), (1)
Host
Goat
(16), (5)
Clonality
Polyclonal
Application
ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(15), (13), (8), (2), (2), (2), (2), (1)
Pubmed 1 reference available
Quantity 50 µg
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Catalog No. ABIN148489
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Immunogen Synthetic peptide: RVTNQLLGRKVPWD from C Terminus of the protein sequence according to NP_055935.
Isotype IgG
Specificity The C terminus of ALMS 1 shares an 8 amino acid stretch with two other human proteins: hypothetical protein (XP_169104) and ERAL1 (NP_005693). However, this stretch is located internally in these two proteins and so will most likely not cross-react with this antibody. The N terminus was not chosen as the peptide is expected to cyclise during synthesis.
Cross-Reactivity Mouse (Murine)
Purification IgG fraction. Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide..
Alternative Name ALMS1
Background This protein contains a large tandem-repeat domain that contains no cysteine residues. Mutations in this gene have been associated with Alstrom syndrome. The encoded protein may play a role in hearing, sight, obesity, and liver function. Alternative splice variants have been described but their full length sequences have not been determined.
Synonyms: 203800, KIAA0328, ALSS, ALMS1, Q8TCU4, 7840, DKFZp686A118, DKFZp686D1828
Research Area Immunology
Application Notes ELISA: 1/3200. Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user.
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer Tris saline, 0.02% Na azide, pH7.3 with 0.5% BSA
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid freeze-thaw cycles.
Storage -20 °C
Storage Comment Upon receipt - Keep as concentrated solution. Aliquot and store at -20°C or below.
General Collin, Marshall, Ikeda et al.: "Mutations in ALMS1 cause obesity, type 2 diabetes and neurosensory degeneration in Alström syndrome." in: Nature genetics, Vol. 31, Issue 1, pp. 74-8, 2002 (PubMed).

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