NLR Family, Pyrin Domain Containing 3 (NLRP3) (C-Term) antibody

Details for Product No. ABIN148686
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Antigen
Synonyms CIAS1, Nalp3, avp, cias1, nalp3, pypaf1, agtavprl, AGTAVPRL, AII, AVP, C1orf7, CLR1.1, FCAS, FCU, MWS, NALP3, PYPAF1, AII/AVP, Cias1, Mmig1, Pypaf1
Epitope
C-Term
(24), (6), (5), (3), (3), (2), (2), (2), (2), (1), (1), (1), (1)
Reactivity
Human
(86), (25), (19), (6), (5), (3), (2), (1)
Host
Goat
(50), (19), (17), (2)
Clonality
Polyclonal
Conjugate
Un-conjugated
(2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
ELISA, Western Blotting (WB)
(63), (39), (19), (15), (10), (8), (6), (6), (4), (3), (3), (2), (2), (1)
Pubmed 1 reference available
Quantity 0.1 mg
Shipping to United States (Change)
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The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN148686
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Immunogen Peptide with sequence EKPELTVVFEPSW, from C Terminus of the protein sequence according to NP_004886
Isotype IgG
Cross-Reactivity Rat (Rattus)
Purification IgG fraction. Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide..
Alternative Name NALP3
Background This gene encodes a pyrin-like protein containing a pyrin domain, a nucleotide-binding site (NBS) domain, and a leucine-rich repeat (LRR) motif. This protein interacts with the apoptosis-associated speck-like protein PYCARD/ASC, which contains a caspase recruitment domain, and is a member of the NALP3 inflammasome complex. This complex functions as an upstream activator of NF-kappaB signaling, and it plays a role in the regulation of inflammation, the immune response, and apoptosis. Mutations in this gene are associated with familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS), chronic infantile neurological cutaneous and articular (CINCA) syndrome, and neonatal-onset multisystem inflammatory disease (NOMID). Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Alternative 5&apos, UTR structures are suggested by available data, however, insufficient evidence is available to determine if all of the represented 5&apos, UTR splice patterns are biologically valid. [provided by RefSeq]
Synonyms: AII/AVP, AGTAVPRL, PYPAF1, 114548, C1orf7, CIAS1, FCAS, 120100, Q96P20, NALP3, MWS, FCU, AII, AVP, CLR1.1, FLJ95925
Application Notes ELISA: peptide ELISA (antibody detection limit dilution >1/32000). Western blot: No signal obtained yet but low background observed in Daudi, A431, Jurkat, U937 and MOLT 4 lysates at up to 1.0 ug/ml.
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer Tris saline, 0.02% Na azide, pH7.3 with 0.5% BSA
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid freeze-thaw cycles.
Storage -20 °C
Storage Comment Upon receipt - Keep as concentrated solution. Aliquot and store at -20°C or below.
General Hoffman, Mueller, Broide et al.: "Mutation of a new gene encoding a putative pyrin-like protein causes familial cold autoinflammatory syndrome and Muckle-Wells syndrome." in: Nature genetics, Vol. 29, Issue 3, pp. 301-5, 2001 (PubMed).

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