Interferon Regulatory Factor 5 (IRF5) (C-Term) antibody

Details for Product No. ABIN148742
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Antigen
Synonyms IRF5, irf5, SLEB10, AW491843, mirf5, im:7155364, zgc:76986
Epitope
C-Term
(8), (8), (6), (4), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(56), (23), (12), (5), (4), (2), (1), (1), (1)
Host
Goat
(30), (28), (8), (1)
Clonality
Polyclonal
Application
Western Blotting (WB)
(59), (34), (20), (12), (11), (9), (7), (3), (2), (2), (2)
Pubmed 2 references available
Quantity 0.1 mg
Shipping to United States (Change)
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Catalog No. ABIN148742
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Immunogen Peptide with sequence QGPWPMHPAGMQ, from C Terminus of the protein sequence according to NP_002191, NP_116032
Isotype IgG
Specificity This antibody is expected to recognise both human isoforms.
Purification IgG fraction. Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide..
Alternative Name IRF5
Background This gene encodes a member of the interferon regulatory factor (IRF) family, a group of transcription factors with diverse roles, including virus-mediated activation of interferon, and modulation of cell growth, differentiation, apoptosis, and immune system activity. Members of the IRF family are characterized by a conserved N-terminal DNA-binding domain containing tryptophan (W) repeats. Alternative splice variants encoding different isoforms exist. [provided by RefSeq]
Synonyms: SLEB10
Research Area Chromatin and Nuclear Signaling, Transcription Factors, Innate Immunity, Cytokines
Application Notes Western Blot-Approx 55-60kDa band seen in A549 lysate (predicted MW 58 kDa). Recommended for use at 1.0-3.0ug/ml.
Comment

Positive Controls: A549 lysate

Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer Tris saline, 0.02% Na azide, pH7.3 with 0.5% BSA
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid freeze-thaw cycles.
Storage -20 °C
Storage Comment Upon receipt - Keep as concentrated solution. Aliquot and store at -20°C or below.
General Lefkowitz: "Identification of adenylate cyclase-coupled beta-adrenergic receptors with radiolabeled beta-adrenergic antagonists." in: Biochemical pharmacology, Vol. 24, Issue 18, pp. 1651-8, 1976 (PubMed).

Barnes, Moore, Pitha: "Virus-specific activation of a novel interferon regulatory factor, IRF-5, results in the induction of distinct interferon alpha genes." in: The Journal of biological chemistry, Vol. 276, Issue 26, pp. 23382-90, 2001 (PubMed).

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