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Ephrin Type A Receptor 1 (EPHA1) (Extracellular Domain) antibody

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Synonyms EPH, EPHT, EPHT1, 5730453L17Rik, AL033318, Eph, Esk, EPHA9
Extracellular Domain
(28), (21), (15), (14), (12), (11), (6), (6), (3), (3), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1)
(108), (46), (11), (3), (3), (3), (1)
(121), (16)
(8), (8), (6), (6), (6), (6)
ELISA, Western Blotting (WB)
(124), (84), (60), (20), (18), (11), (6), (6), (3), (1)
Pubmed 9 references available
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Quantity 50 μg
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Immunogen Recombinant fragment (extracellular domain) (Human). Expressed in NSO cells.
Isotype IgG
Specificity The antibody will recognize recombinant human EphA1 by immunoblotting and ELISA. By immunoblotting and ELISA, the antibody shows approximately 40% cross-reactivity with recombinant mouse EphA3, mouse EphA8, mouse EphA4, rat EphA5 and 10% cross-reactivity with recombinant mouse EphA2, mouse EphA6 and mouse EphA7.
Purification Immunogen affinity purified.
Alternative Name EPHA1 (EPHA1 Antibody Abstract)
Background The Eph family of receptors comprises the largest known family of receptor tyrosine kinases. Ligands of Eph family receptors are structurally related membrane-bound proteins that can be subdivided into two major subclasses, ephrin-A and ephrin-B. Expression of Eph receptors is tissue specific and appears to be tied to developmental events. Ligands in the ephrin-A subclass, including the prototype family member ephrin-A1 (B61), are membrane associated through glycosylphosphatidyl-inositol linkages, whereas ephrin-B subclass consists of ligands with transmembrane domains. The general role of the Eph family is in mediating repulsive cell-cell interaction.
Synonyms: EPHT, 179610, 2041, EPHT1, EphA1, EPH, P21709
Application Notes I-ELISA: Use at a concentration of 0.5-1.0 ug/ml. WB (colorimetric): Use at a concentration of 0.1-0.2 ug/ml. Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user.
Restrictions For Research Use only
Buffer 0.01M Na phosphate, 0.15M NaCl, pH7.6
Handling Advice Avoid freeze-thaw cycles.
Storage 4 °C
Storage Comment Keep as concentrated solution. Store at 4°C short term. For extended storage aliquot and store at -20°C or below.
Background publications Krull, Lansford, Gale et al.: "Interactions of Eph-related receptors and ligands confer rostrocaudal pattern to trunk neural crest migration." in: Current biology : CB, Vol. 7, Issue 8, pp. 571-80, 1997 (PubMed).

Smith, Robinson, Patel et al.: "The EphA4 and EphB1 receptor tyrosine kinases and ephrin-B2 ligand regulate targeted migration of branchial neural crest cells." in: Current biology : CB, Vol. 7, Issue 8, pp. 561-70, 1997 (PubMed).

Wang, Anderson: "Eph family transmembrane ligands can mediate repulsive guidance of trunk neural crest migration and motor axon outgrowth." in: Neuron, Vol. 18, Issue 3, pp. 383-96, 1997 (PubMed).

Nakamoto, Cheng, Friedman et al.: "Topographically specific effects of ELF-1 on retinal axon guidance in vitro and retinal axon mapping in vivo." in: Cell, Vol. 86, Issue 5, pp. 755-66, 1996 (PubMed).

Gale, Holland, Valenzuela et al.: "Eph receptors and ligands comprise two major specificity subclasses and are reciprocally compartmentalized during embryogenesis." in: Neuron, Vol. 17, Issue 1, pp. 9-19, 1996 (PubMed).

Henkemeyer, Orioli, Henderson et al.: "Nuk controls pathfinding of commissural axons in the mammalian central nervous system." in: Cell, Vol. 86, Issue 1, pp. 35-46, 1996 (PubMed).

Cheng, Nakamoto, Bergemann et al.: "Complementary gradients in expression and binding of ELF-1 and Mek4 in development of the topographic retinotectal projection map." in: Cell, Vol. 82, Issue 3, pp. 371-81, 1995 (PubMed).

Drescher, Kremoser, Handwerker et al.: "In vitro guidance of retinal ganglion cell axons by RAGS, a 25 kDa tectal protein related to ligands for Eph receptor tyrosine kinases." in: Cell, Vol. 82, Issue 3, pp. 359-70, 1995 (PubMed).

Fraser, Keynes, Lumsden: "Segmentation in the chick embryo hindbrain is defined by cell lineage restrictions." in: Nature, Vol. 344, Issue 6265, pp. 431-5, 1990 (PubMed).

Catalog No. ABIN149243
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