Antigen Identified By Monoclonal Antibody Ki-67 (MKI67) antibody

Details for Product No. ABIN149263
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Antigen
Synonyms MKI67, kia, mki67, MGC132156, D630048A14Rik, Ki-67, Ki67, KIA, MIB-1
Reactivity
Human
(199), (30), (28), (2), (1), (1)
Host
Rabbit
(123), (76), (6), (2), (2)
Clonality
Polyclonal
Conjugate
Un-conjugated
(2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (IHC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(94), (68), (61), (58), (36), (27), (16), (10), (9), (1), (1)
Pubmed 2 references available
Quantity 0.5 mL
Shipping to United States (Change)
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Catalog No. ABIN149263
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Immunogen Synthetic peptide from the human Ki-67 allantigen.
Isotype IgG
Cross-Reactivity Rat (Rattus), Mouse (Murine)
Characteristics Cellular Localization: Nuclear
Purification Protein A affinity purified.
Alternative Name Ki-67
Background Ki-67 antigen is the prototypic cell cycle related nuclear protein, expressed by proliferating cells in all phases of the active cell cycle (G1, S, G2 and M phase). It is absent in resting (G0) cells. Ki67 antibodies are useful in establishing the cell growing fraction in neoplasms (immunohistochemically quantified by determining the number of Ki67-positive cells among the total number of resting cells = Ki67 index). In neoplastic tissues the prognostic value is comparable to the tritiated thymidine-labelling index. The correlation between low Ki67 index and histologically low-grade tumours is strong.
Synonyms: KIA
Research Area Proliferation Markers, Cell Cycle
Application Notes IHC-P: Use at
Comment

Positive Controls: Tonsil or Breast carcinoma

Restrictions For Research Use only
Format Liquid
Concentration 1 mg/mL
Buffer 10mM Phosphate-buffered saline containing 0.2% BSA and 0.1% sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Do not freeze
Storage 4 °C
Storage Comment Keep as concentrated solution, aliquot and store at 4°C.
Supplier Images
anti-Antigen Identified By Monoclonal Antibody Ki-67 (MKI67) antibody anti-Antigen Identified By Monoclonal Antibody Ki-67 (MKI67) antibody
General Gerdes, Li, Schlueter et al.: "Immunobiochemical and molecular biologic characterization of the cell proliferation-associated nuclear antigen that is defined by monoclonal antibody Ki-67." in: The American journal of pathology, Vol. 138, Issue 4, pp. 867-73, 1991 (PubMed).

Bonhomme, Duluc, Martin et al.: "The Cdx2 homeobox gene has a tumour suppressor function in the distal colon in addition to a homeotic role during gut development." in: Gut, Vol. 52, Issue 10, pp. 1465-71, 2003 (PubMed).

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