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KI-67 antibody (Antigen Identified By Monoclonal antibody Ki-67)

Details for Product anti-MKI67 Antibody No. ABIN149263, Supplier: Login to see
Antigen
  • MKI67
  • kia
  • mki67
  • MGC132156
  • D630048A14Rik
  • Ki-67
  • Ki67
  • KIA
  • MIB-1
Reactivity
Human
354
60
32
25
11
11
5
3
Host
Rabbit
164
141
43
10
3
Clonality
Polyclonal
Conjugate
This KI-67 antibody is un-conjugated
12
8
8
5
5
5
4
4
4
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
Application
Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (IHC)
128
111
105
84
62
37
36
31
18
10
10
6
6
3
3
3
2
1
1
1
Supplier
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Immunogen Synthetic peptide from the human Ki-67 allantigen.
Isotype IgG
Cross-Reactivity Rat (Rattus), Mouse (Murine)
Characteristics Cellular Localization: Nuclear
Purification Protein A affinity purified.
Alternative Name Ki-67 (MKI67 Antibody Abstract)
Background Ki-67 antigen is the prototypic cell cycle related nuclear protein, expressed by proliferating cells in all phases of the active cell cycle (G1, S, G2 and M phase). It is absent in resting (G0) cells. Ki67 antibodies are useful in establishing the cell growing fraction in neoplasms (immunohistochemically quantified by determining the number of Ki67-positive cells among the total number of resting cells = Ki67 index). In neoplastic tissues the prognostic value is comparable to the tritiated thymidine-labelling index. The correlation between low Ki67 index and histologically low-grade tumours is strong.
Synonyms: KIA
Research Area Proliferation Markers, Cell Cycle
Pathways
Application Notes IHC-P: Use at
Comment

Positive Controls: Tonsil or Breast carcinoma

Restrictions For Research Use only
Format Liquid
Concentration 1 mg/mL
Buffer 10mM Phosphate-buffered saline containing 0.2% BSA and 0.1% sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Do not freeze
Storage 4 °C
Storage Comment Keep as concentrated solution, aliquot and store at 4°C.
Supplier Images
 image for anti-KI-67 antibody (Antigen Identified By Monoclonal antibody Ki-67) (ABIN149263) anti-Antigen Identified By Monoclonal Antibody Ki-67 (MKI67) antibody
Background publications Bonhomme, Duluc, Martin et al.: "The Cdx2 homeobox gene has a tumour suppressor function in the distal colon in addition to a homeotic role during gut development." in: Gut, Vol. 52, Issue 10, pp. 1465-71, 2003 (PubMed).

Gerdes, Li, Schlueter et al.: "Immunobiochemical and molecular biologic characterization of the cell proliferation-associated nuclear antigen that is defined by monoclonal antibody Ki-67." in: The American journal of pathology, Vol. 138, Issue 4, pp. 867-73, 1991 (PubMed).