Antigen Identified By Monoclonal Antibody Ki-67 (MKI67) antibody

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Antigen
Synonyms KIA, MIB-1, Ki67, Ki-67, D630048A14Rik, MKI67, kia, mki67, MGC132156
Reactivity
Human
(193), (33), (27), (2), (1), (1), (1)
Host
Rabbit
(117), (81), (6), (2)
Clonality
Polyclonal
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(95), (75), (61), (55), (31), (24), (19), (10), (9), (7), (3), (1), (1), (1)
Pubmed 2 references available
Catalog no. ABIN149263
Quantity 0.5 mL
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Immunogen Synthetic peptide from the human Ki-67 allantigen.
Isotype IgG
Cross-Reactivity Rat (Rattus)
Purification Protein A affinity purified
Alternative Name Ki-67
Background Ki-67 antigen is the prototypic cell cycle related nuclear protein, expressed by proliferating cells in all phases of the active cell cycle (G1, S, G2 and M phase). It is absent in resting (G0) cells. Ki67 antibodies are useful in establishing the cell growing fraction in neoplasms (immunohistochemically quantified by determining the number of Ki67-positive cells among the total number of resting cells = Ki67 index). In neoplastic tissues the prognostic value is comparable to the tritiated thymidine-labelling index. The correlation between low Ki67 index and histologically low-grade tumours is strong.
Research Area Proliferation Markers, Cell Cycle
Application Notes IHC-P: Use at
Restrictions For Research Use only
Format Liquid
Concentration batch dependent
Buffer 10mM PBS, pH7.4
Preservative Sodium azide
Storage 4 °C
Supplier Images
anti-Antigen Identified By Monoclonal Antibody Ki-67 (MKI67) antibody anti-Antigen Identified By Monoclonal Antibody Ki-67 (MKI67) antibody
General Gerdes, Li, Schlueter et al.: "Immunobiochemical and molecular biologic characterization of the cell proliferation-associated nuclear antigen that is defined by monoclonal antibody Ki-67." in: The American journal of pathology, Vol. 138, Issue 4, pp. 867-73, 1991 (PubMed).

Bonhomme, Duluc, Martin et al.: "The Cdx2 homeobox gene has a tumour suppressor function in the distal colon in addition to a homeotic role during gut development." in: Gut, Vol. 52, Issue 10, pp. 1465-71, 2003 (PubMed).

Hosts (117), (81), (6), (2)
Reactivities (193), (33), (27), (2), (1), (1), (1)
Applications (95), (75), (61), (55), (31), (24), (19), (10), (9), (7), (3), (1), (1), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (25), (8), (5), (4), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
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