Caspase 6, Apoptosis-Related Cysteine Peptidase (CASP6) (activated) antibody

Details for Product No. ABIN149585
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Antigen
Synonyms xCaspase-6, mch2, caspase-6, zgc:112960, CASP6, casp6, Mch2, mCASP-6, MCH2
Epitope
activated
(49), (35), (23), (12), (12), (9), (7), (7), (4), (3), (3), (3), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(200), (92), (79), (13), (6), (2), (1)
Host
Rabbit
(188), (27), (4)
Clonality
Polyclonal
Conjugate
Un-conjugated
(11), (10), (8), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4)
Application
Western Blotting (WB)
(179), (98), (67), (54), (40), (33), (25), (15), (8), (5), (1), (1), (1)
Pubmed 2 references available
Quantity 50 μg
Shipping to United States (Change)
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Catalog No. ABIN149585
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Immunogen Available on request
Isotype IgG
Specificity This antibody recognizes the large subunit (18 kDa) of the active caspase 6. The antibody does not recognize any other caspase.
Cross-Reactivity Mouse (Murine), Rat (Rattus)
Purification Immunogen affinity purified.
Alternative Name Caspase-6
Background The caspase family of cysteine proteases has been shown to play a key role in apoptosis. Similar to other caspases, caspase 6 is also synthesized as an inactive pro-enzyme that is processed in cells undergoing apoptosis. Together with caspase 3, caspase 6 is one of the major caspases in apoptotic cells, and functions downstream of apoptosis inhibitors Bcl-2 and Bcl-xL. Caspase 6 has also been shown involving in the proteolysis of poly (ADP-ribose) polymerase (PARP) and nuclear lamin A.
Synonyms: P55212, CASP6, MCH2, 839, Caspase 6 active, 601532, Caspase6 active, Caspase 6 (Active), Active Caspase 6
Research Area Apoptosis/Necrosis
Application Notes WB: Use at a concentration of 1 ug/ml. Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user.
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 1 mg/ml BSA, 1.5 mM sodium azide and 50% glycerol
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid freeze-thaw cycles.
Storage 4 °C
Storage Comment Keep as concentrated solution. Store at 4°C short term. For extended storage aliquot and store at -20°C or below.
General Jenkins, Davis, Boulos: "Transfer of drugs across the ruminal wall in goats." in: American journal of veterinary research, Vol. 36, Issue 12, pp. 1771-6, 1976 (PubMed).

Faleiro, Kobayashi, Fearnhead et al.: "Multiple species of CPP32 and Mch2 are the major active caspases present in apoptotic cells." in: The EMBO journal, Vol. 16, Issue 9, pp. 2271-81, 1997 (PubMed).

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