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Caspase 6, Apoptosis-Related Cysteine Peptidase (CASP6) (activated) antibody

Antigen

Caspase 6, Apoptosis-Related Cysteine Peptidase (CASP6)
Synonyms MCH2, Mch2, mCASP-6, MGC93335, xCaspase-6, mch2, caspase-6, CASP6, MGC127633, zgc:112960, casp6
Binding Site
Alternatives

activated
Clonality Polyclonal
Host
Alternatives

Rabbit
Reactivity
Alternatives

Human
Conjugate
Alternatives Un-conjugated
Application
Alternatives Western Blotting (WB)
2 references available
Catalog no. ABIN149585
Quantity 50 µg  (0.5 mg/ml)
Price Product not available in this region.
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Additional Information
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Alternative name Caspase-6
Immunogen Available on request
Cross-Reactivity Human, Mouse (Murine), Rat (Rattus)
Isotype IgG
Description The caspase family of cysteine proteases has been shown to play a key role in apoptosis. Similar to other caspases, caspase 6 is also synthesized as an inactive pro-enzyme that is processed in cells undergoing apoptosis. Together with caspase 3, caspase 6 is one of the major caspases in apoptotic cells, and functions downstream of apoptosis inhibitors Bcl-2 and Bcl-xL. Caspase 6 has also been shown involving in the proteolysis of poly (ADP-ribose) polymerase (PARP) and nuclear lamin A.
Specificity This antibody recognizes the large subunit (18 kDa) of the active caspase 6. The antibody does not recognize any other caspase.

Application Details
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Application Notes WB: Use at a concentration of 1 ug/ml. Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user.
Concentration 0.5 mg/ml
Purification Immunogen affinity purified
Buffer PBS, 50% glycerol
Preservative 1 mg/ml BSA, 1.5 mM sodium azide
Storage Store at -20 C. For long term storage, aliquot and refreeze at -70 C. Avoid repeated freeze/defrost cycles.
Research Area Apoptosis/Necrosis
Restrictions For Research Use only

Publications
Application Details Alternatives back to top

Jenkins, Davis, Boulos: "Transfer of drugs across the ruminal wall in goats." in: American journal of veterinary research, Vol. 36, Issue 12, pp. 1771-6, 1976 (PubMed).

Faleiro, Kobayashi, Fearnhead et al.: "Multiple species of CPP32 and Mch2 are the major active caspases present in apoptotic cells." in: The EMBO journal, Vol. 16, Issue 9, pp. 2271-81, 1997 (PubMed).

Alternatives
Application Details Publications back to top

Alternatives for antigen "Caspase 6, Apoptosis-Related Cysteine Peptidase (CASP6)", type "Antibodies"
Hosts Rabbit (76), Mouse (13)
Reactivities Human (77), Rat (Rattus) (24), Mouse (Murine) (20), Cow (Bovine) (5), Dog (Canine) (4), Cat (Feline) (1), Chicken (1), Hamster (1), Monkey (1), Pig (Porcine) (1), Rabbit (1), Sheep (Ovine) (1)
Applications Western Blotting (WB) (78), ELISA (38), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (26), Immunohistochemistry (IHC) (21), Immunofluorescence (IF) (15), Immunoprecipitation (IP) (12), Immunocytochemistry (ICC) (8), Flow Cytometry (FACS) (3), Immunohistochemistry (Fixed) (IHC (fx)) (2), Immunohistochemistry (Frozen Sections) (IHC (fro)) (1)
Conjugates Biotin (2), Alexa Fluor 350 (1), Alexa Fluor 488 (1), Alexa Fluor 555 (1), Alexa Fluor 647 (1), FITC (1), PE,Cy5.5 (1)
Epitopes C-Term (10), N-Term (8), pSer257 (8), Internal Region (4), Cleaved-Asp162 (2), Ser257 (2), AA 250-264 (1), C-Term,active (1), Center (1), Cleavage Site (1), Middle Region (1), Pro-form (1), Prodomain (1), active (1), cleaved (1), pSer146 (1)