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Caspase 6 antibody (Caspase 6, Apoptosis-Related Cysteine Peptidase) (activated)

Details for Product anti-CASP6 Antibody No. ABIN149585, Supplier: Login to see
Antigen
  • xCaspase-6
  • mch2
  • caspase-6
  • zgc:112960
  • CASP6
  • casp6
  • Mch2
  • mCASP-6
  • MCH2
Alternatives
anti-Human Caspase 6 antibody for Immunohistochemistry (Paraffin-embedded Sections)
Epitope
activated
58
41
34
23
17
15
13
13
11
6
6
5
5
5
4
4
3
3
3
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
284
82
79
15
3
2
Host
Rabbit
280
19
19
Clonality
Polyclonal
Conjugate
This Caspase 6 antibody is un-conjugated
19
18
14
11
11
11
4
3
3
3
3
3
3
3
3
Application
Western Blotting (WB)
262
154
109
57
35
26
25
16
9
6
5
5
1
Supplier
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Immunogen Available on request
Isotype IgG
Specificity This antibody recognizes the large subunit (18 kDa) of the active caspase 6. The antibody does not recognize any other caspase.
Cross-Reactivity Mouse (Murine), Rat (Rattus)
Purification Immunogen affinity purified.
Alternative Name Caspase-6 (CASP6 Antibody Abstract)
Background The caspase family of cysteine proteases has been shown to play a key role in apoptosis. Similar to other caspases, caspase 6 is also synthesized as an inactive pro-enzyme that is processed in cells undergoing apoptosis. Together with caspase 3, caspase 6 is one of the major caspases in apoptotic cells, and functions downstream of apoptosis inhibitors Bcl-2 and Bcl-xL. Caspase 6 has also been shown involving in the proteolysis of poly (ADP-ribose) polymerase (PARP) and nuclear lamin A.
Synonyms: P55212, CASP6, MCH2, 839, Caspase 6 active, 601532, Caspase6 active, Caspase 6 (Active), Active Caspase 6
Research Area Apoptosis/Necrosis
Pathways Apoptosis, Caspase Cascade in Apoptosis
Application Notes WB: Use at a concentration of 1 ug/ml. Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user.
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 1 mg/ml BSA, 1.5 mM sodium azide and 50% glycerol
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid freeze-thaw cycles.
Storage 4 °C
Storage Comment Keep as concentrated solution. Store at 4°C short term. For extended storage aliquot and store at -20°C or below.
Background publications Faleiro, Kobayashi, Fearnhead et al.: "Multiple species of CPP32 and Mch2 are the major active caspases present in apoptotic cells." in: The EMBO journal, Vol. 16, Issue 9, pp. 2271-81, 1997 (PubMed).

Jenkins, Davis, Boulos: "Transfer of drugs across the ruminal wall in goats." in: American journal of veterinary research, Vol. 36, Issue 12, pp. 1771-6, 1976 (PubMed).