Caspase 6, Apoptosis-Related Cysteine Peptidase (CASP6) (activated) antibody

Details for Product No. ABIN149585
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Antigen
Synonyms MCH2, Mch2, mCASP-6, xCaspase-6, mch2, caspase-6, zgc:112960, CASP6, casp6
Epitope
activated
(41), (27), (22), (10), (7), (6), (4), (3), (3), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(177), (93), (78), (13), (7), (2), (1)
Host
Rabbit
(160), (33), (2)
Clonality
Polyclonal
Conjugate
Un-conjugated
(8), (6), (4), (4), (4), (4), (4), (4), (4), (4), (4)
Application
Western Blotting (WB)
(151), (82), (58), (45), (40), (33), (25), (17), (8), (2), (2), (2), (1), (1), (1)
Pubmed 2 references available
Catalog no. ABIN149585
Quantity 50 µg
Price
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Immunogen Available on request
Isotype IgG
Specificity This antibody recognizes the large subunit (18 kDa) of the active caspase 6. The antibody does not recognize any other caspase.
Cross-Reactivity Mouse (Murine), Rat (Rattus)
Purification Immunogen affinity purified
Alternative Name Caspase-6
Background The caspase family of cysteine proteases has been shown to play a key role in apoptosis. Similar to other caspases, caspase 6 is also synthesized as an inactive pro-enzyme that is processed in cells undergoing apoptosis. Together with caspase 3, caspase 6 is one of the major caspases in apoptotic cells, and functions downstream of apoptosis inhibitors Bcl-2 and Bcl-xL. Caspase 6 has also been shown involving in the proteolysis of poly (ADP-ribose) polymerase (PARP) and nuclear lamin A.
Research Area Apoptosis/Necrosis
Application Notes WB: Use at a concentration of 1 ug/ml. Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user.
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/ml
Buffer PBS, 50% glycerol
Preservative Sodium azide
Storage -20 °C
General Jenkins, Davis, Boulos: "Transfer of drugs across the ruminal wall in goats." in: American journal of veterinary research, Vol. 36, Issue 12, pp. 1771-6, 1976 (PubMed).

Faleiro, Kobayashi, Fearnhead et al.: "Multiple species of CPP32 and Mch2 are the major active caspases present in apoptotic cells." in: The EMBO journal, Vol. 16, Issue 9, pp. 2271-81, 1997 (PubMed).

Hosts (160), (33), (2)
Reactivities (177), (93), (78), (13), (7), (2), (1)
Applications (151), (82), (58), (45), (40), (33), (25), (17), (8), (2), (2), (2), (1), (1), (1)
Conjugates (8), (6), (4), (4), (4), (4), (4), (4), (4), (4), (4)
Epitopes (41), (27), (22), (10), (7), (6), (4), (3), (3), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
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