Accumulating evidence has demonstrated that cytokine receptor signaling is negatively regulated by a family of Srchomology 2 domain-containing adaptor molecules termed SOCS (Suppressor of Cytokine Signaling). To date, there are eight members of SOCS family that have been recognized, they are SOCS 1 - 7 and CIS. Structurally, the SOCS proteins are composed of an N terminal region of variable length and amino acid composition, a central SH2 domain, and a previously unrecognized C-terminal motif that has been called the SOCS box. The SOCS proteins appear to form part of a classical negative feed back loop that regulates cytokine signal transduction via a STAT-induced transcriptional mechanism. Transcription of each of the SOCS genesoccurs rapidly in vitro and in vivo in response to cytokines, and once produced, the various members of the SOCS family appear to inhibit signaling in different ways. SOCS 3 is an important regulator of fetal liverhematopoiesis. It is also involved in a broad spectrum ofcytokines, e.g. IL2, IL3, IL4, IL6, Epo, Prolactin, and GH. Recent findings suggest that aberrant induction of SOCS3 by pathogens, such as Leishmania donovani and hepatitis C virus, might interfere with the host immune response and contribute to the persistent infection by these pathogens.
Synonyms: O14543, MGC71791, Cish3, SOCS3, SSI-3, 604176, 9021, SSI3, SOCS-3, CIS3, SSI 3, SOCS 3