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Suppressor of Cytokine Signaling 3 (SOCS3) antibody

Details for Product No. ABIN150211
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Antigen
Synonyms
SSI-3, SOCS-3, Cis3, Ef10, Ssi3, Cish3, EF-10, Socs-3, Ssi-3, ATOD4, CIS3, SSI3, socs3, fj09e12, zgc:56537, wu:fj09e12, MGC64393, MGC75749, xsocs3, MGC81248, atod4, cis3, cish3, socs-3, ssi-3, ssi3, S ... show more
SSI-3, SOCS-3, Cis3, Ef10, Ssi3, Cish3, EF-10, Socs-3, Ssi-3, ATOD4, CIS3, SSI3, socs3, fj09e12, zgc:56537, wu:fj09e12, MGC64393, MGC75749, xsocs3, MGC81248, atod4, cis3, cish3, socs-3, ssi-3, ssi3, SOCS3 show less
Reactivity
Human
(111), (37), (30), (15), (14), (14), (12), (1)
Host
Goat
(64), (57), (6)
Clonality
Polyclonal
Conjugate
Un-conjugated
(6), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(96), (43), (30), (30), (24), (16), (10), (6), (5), (4), (2), (1)
Pubmed 1 reference available
Quantity 50 µg
Shipping to United States (Change)
Catalog No. ABIN150211
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  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen Synthetic peptide: PIREFLDQYDAPL (Human).
Isotype IgG
Cross-Reactivity Mouse (Murine), Rat (Rattus)
Purification Purified IgG fraction
Alternative Name SOCS3 / CIS3
Background Accumulating evidence has demonstrated that cytokine receptor signaling is negatively regulated by a family of Srchomology 2 domain-containing adaptor molecules termed SOCS (Suppressor of Cytokine Signaling). To date, there are eight members of SOCS family that have been recognized, they are SOCS 1-7 and CIS. Structurally, the SOCS proteins are composed of an N terminal region of variable length and amino acid composition, a central SH2 domain, and a previously unrecognized C-terminal motif that has been called the SOCS box. The SOCS proteins appear to form part of a classical negative feed back loop that regulates cytokine signal transduction via a STAT-induced transcriptional mechanism. Transcription of each of the SOCS genesoccurs rapidly in vitro and in vivo in response to cytokines, and once produced, the various members of the SOCS family appear to inhibit signaling in different ways. SOCS 3 is an important regulator of fetal liverhematopoiesis. It is also involved in a broad
Application Notes Western Blot-Approx 24kDa band seen in MOLT-4 lysate. Recommended for use at 4.0-6.0ug/ml.
Restrictions For Research Use only
Concentration 0.5 mg/ml
Buffer Tris saline, 0.02% Na azide, pH7.3 with 0.5% BSA
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
General Roberts, Robb, Rakar et al.: "Placental defects and embryonic lethality in mice lacking suppressor of cytokine signaling 3." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 98, Issue 16, pp. 9324-9, 2001 (PubMed).

Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN150211
Contact our Customer Service for availability and price in your country.
Add to Basket

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
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