Suppressor of Cytokine Signaling 3 (SOCS3) antibody

Antigen: Suppressor of Cytokine Signaling 3 (SOCS3)

Synonyms: SSI-3, socs3, fj09e12, zgc:56537, wu:fj09e12, MGC64393, MGC75749, xsocs3, MGC81248, SOCS-3, cis3, ssi3, atod4, cish3, ssi-3, socs-3, MGC88877, SOCS3

Clonality: Polyclonal

Host: Goat

Reactivity: Human

Conjugate: Un-conjugated

Application: Western Blotting (WB)

Catalog no.: ABIN150211

Additional Information

Alternative name: SOCS3 / CIS3

Immunogen: Synthetic peptide: PIREFLDQYDAPL (Human).

Cross-Reactivity: Human, Mouse (Murine), Rat (Rattus)

Isotype: IgG

Description: Accumulating evidence has demonstrated that cytokine receptor signaling is negatively regulated by a family of Srchomology 2 domain-containing adaptor molecules termed SOCS (Suppressor of Cytokine Signaling). To date, there are eight members of SOCS family that have been recognized, they are SOCS 1-7 and CIS. Structurally, the SOCS proteins are composed of an N terminal region of variable length and amino acid composition, a central SH2 domain, and a previously unrecognized C-terminal motif that has been called the SOCS box. The SOCS proteins appear to form part of a classical negative feed back loop that regulates cytokine signal transduction via a STAT-induced transcriptional mechanism. Transcription of each of the SOCS genesoccurs rapidly in vitro and in vivo in response to cytokines, and once produced, the various members of the SOCS family appear to inhibit signaling in different ways. SOCS 3 is an important regulator of fetal liverhematopoiesis. It is also involved in a broad

Application Details

Application Notes: Western Blot-Approx 24kDa band seen in MOLT-4 lysate. Recommended for use at 4.0-6.0ug/ml.

Concentration: 0.5 mg/ml

Purification: Purified IgG fraction

Buffer: Tris saline, 0.02% Na azide, pH7.3 with 0.5% BSA

Storage: Aliquot and store at -20 C. Minimize freezing and thawing.

Restrictions: For Research Use only

Publications

Roberts, Robb, Rakar et al.: "Placental defects and embryonic lethality in mice lacking suppressor of cytokine signaling 3." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 98, Issue 16, pp. 9324-9, 2001 (PubMed).