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SOCS3 antibody (Suppressor of Cytokine Signaling 3)

Details for Product anti-SOCS3 Antibody No. ABIN150211, Supplier: Login to see
Antigen
  • socs3
  • fj09e12
  • zgc:56537
  • wu:fj09e12
  • MGC64393
  • MGC75749
  • xsocs3
  • MGC81248
  • atod4
  • cis3
  • cish3
  • socs-3
  • ssi-3
  • ssi3
  • SOCS3
  • ATOD4
  • CIS3
  • Cish3
  • SOCS-3
  • SSI-3
  • SSI3
  • Cis3
  • EF-10
  • Ef10
  • Ssi3
  • Socs-3
  • Ssi-3
Alternatives
anti-Human SOCS3 antibody for Western Blotting
Reactivity
Human
154
42
31
6
6
6
2
2
1
1
1
Host
Goat
84
77
16
Clonality
Polyclonal
Conjugate
This SOCS3 antibody is un-conjugated
7
4
1
1
1
1
1
Application
Western Blotting (WB)
142
67
45
36
27
24
6
4
3
2
2
2
1
1
Supplier
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Immunogen Synthetic peptide: PIREFLDQYDAPL (Human).
Isotype IgG
Cross-Reactivity Mouse (Murine), Rat (Rattus)
Purification IgG fraction. Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide..
Alternative Name SOCS3 / CIS3 (SOCS3 Antibody Abstract)
Background Accumulating evidence has demonstrated that cytokine receptor signaling is negatively regulated by a family of Srchomology 2 domain-containing adaptor molecules termed SOCS (Suppressor of Cytokine Signaling). To date, there are eight members of SOCS family that have been recognized, they are SOCS 1 - 7 and CIS. Structurally, the SOCS proteins are composed of an N terminal region of variable length and amino acid composition, a central SH2 domain, and a previously unrecognized C-terminal motif that has been called the SOCS box. The SOCS proteins appear to form part of a classical negative feed back loop that regulates cytokine signal transduction via a STAT-induced transcriptional mechanism. Transcription of each of the SOCS genesoccurs rapidly in vitro and in vivo in response to cytokines, and once produced, the various members of the SOCS family appear to inhibit signaling in different ways. SOCS 3 is an important regulator of fetal liverhematopoiesis. It is also involved in a broad spectrum ofcytokines, e.g. IL2, IL3, IL4, IL6, Epo, Prolactin, and GH. Recent findings suggest that aberrant induction of SOCS3 by pathogens, such as Leishmania donovani and hepatitis C virus, might interfere with the host immune response and contribute to the persistent infection by these pathogens.
Synonyms: O14543, MGC71791, Cish3, SOCS3, SSI-3, 604176, 9021, SSI3, SOCS-3, CIS3, SSI 3, SOCS 3
Pathways JAK-STAT Signaling
Application Notes Western Blot-Approx 24kDa band seen in MOLT-4 lysate. Recommended for use at 4.0-6.0ug/ml.
Comment

Positive Controls: MOLT-4 lysate

Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer Tris saline, 0.02% Na azide, pH7.3 with 0.5% BSA
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid freeze-thaw cycles.
Storage -20 °C
Storage Comment Upon receipt - Keep as concentrated solution. Aliquot and store at -20°C or below.
Supplier Images
Western Blotting (WB) image for anti-SOCS3 antibody (Suppressor of Cytokine Signaling 3) (ABIN150211) anti-Suppressor of Cytokine Signaling 3 (SOCS3) antibody
Background publications Roberts, Robb, Rakar et al.: "Placental defects and embryonic lethality in mice lacking suppressor of cytokine signaling 3." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 98, Issue 16, pp. 9324-9, 2001 (PubMed).