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Details for Product No. ABIN150211

Suppressor of Cytokine Signaling 3 (SOCS3) antibody

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SSI-3, SOCS-3, Cis3, Ef10, Ssi3, Cish3, EF-10, Socs-3, Ssi-3, ATOD4, CIS3, SSI3, socs3, fj09e12, zgc:56537, wu:fj09e12, MGC64393, MGC75749, xsocs3, MGC81248, atod4, cis3, cish3, socs-3, ssi-3, ssi3, S ... show more
»Alternatives Human
Clonality Polyclonal
»Alternatives Un-conjugated
»Alternatives Western Blotting (WB)
Pubmed 1 reference available
Catalog no. ABIN150211
Quantity 50 µg
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Immunogen Synthetic peptide: PIREFLDQYDAPL (Human).
Isotype IgG
Cross-Reactivity Mouse (Murine), Rat (Rattus)
Purification Purified IgG fraction
Alternative Name SOCS3 / CIS3
Background Accumulating evidence has demonstrated that cytokine receptor signaling is negatively regulated by a family of Srchomology 2 domain-containing adaptor molecules termed SOCS (Suppressor of Cytokine Signaling). To date, there are eight members of SOCS family that have been recognized, they are SOCS 1-7 and CIS. Structurally, the SOCS proteins are composed of an N terminal region of variable length and amino acid composition, a central SH2 domain, and a previously unrecognized C-terminal motif that has been called the SOCS box. The SOCS proteins appear to form part of a classical negative feed back loop that regulates cytokine signal transduction via a STAT-induced transcriptional mechanism. Transcription of each of the SOCS genesoccurs rapidly in vitro and in vivo in response to cytokines, and once produced, the various members of the SOCS family appear to inhibit signaling in different ways. SOCS 3 is an important regulator of fetal liverhematopoiesis. It is also involved in a broad
Application Notes Western Blot-Approx 24kDa band seen in MOLT-4 lysate. Recommended for use at 4.0-6.0ug/ml.
Restrictions For Research Use only
Concentration 0.5 mg/ml
Buffer Tris saline, 0.02% Na azide, pH7.3 with 0.5% BSA
Preservative Sodium azide
Storage -20 °C
Roberts, Robb, Rakar et al.: "Placental defects and embryonic lethality in mice lacking suppressor of cytokine signaling 3." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 98, Issue 16, pp. 9324-9, 2001 (PubMed).

Alternatives for antigen "Suppressor of Cytokine Signaling 3 (SOCS3)", type "Antibodies"
Hosts (57), (56), (7)
Reactivities (105), (37), (29), (15), (14), (14), (12), (1)
Applications (92), (43), (31), (23), (20), (16), (10), (4), (4), (4), (3), (1), (1)
Conjugates (7), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (11), (9), (4), (3), (3), (2), (1), (1)