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Tumor Necrosis Factor Receptor Superfamily, Member 17 (TNFRSF17) antibody

Antigen

Tumor Necrosis Factor Receptor Superfamily, Member 17 (TNFRSF17)
Synonyms BCM, BCMA, CD269, TNFRSF17
Clonality Polyclonal
Host
Alternatives

Rabbit
Reactivity
Alternatives

Human
Conjugate
Alternatives Un-conjugated
Application
Alternatives Western Blotting (WB)
3 references available
Catalog no. ABIN150438
Quantity 0.1 mg  (0.5 mg/ml)
Price Product not available in this region.
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Additional Information
Application Details Publications Alternatives back to top

Alternative name CD269 / BCMA
Immunogen Synthetic peptide (Human).
Cross-Reactivity Human
Isotype IgG
Description Members in the TNF superfamily regulate immune responses and induce apoptosis. Two novel members in the TNF family were recently identified and designated BAFF/BLyS/TALL1/THANK/zTNF4 and April/TALL2, respectively. BAFF was characterized as a B cell activator since it induced B cell proliferation and immunoglobulin secretion. April regulates immunological and non immunological cell growth. Three receptors, BCMA (for B cell maturation protein), TACI, and BAFFR, for BAFF were recently identified. BCMA, like TACI, binds BAFF and April. BAFF and its receptors induce B cell development and survival, activate NF-kappaB and c-jun N-terminal kinase, and are involved in B cell associated autoimmune diseases.

Application Details
Publications Alternatives back to top

Application Notes WB: Use at a concentration of 2-5 ug/ml. A band of approximately 27 kD is detected using K562 cell lysate as a positive control. Optimal dilutions/concentrations should be determined by the end user.
Concentration 0.5 mg/ml
Purification Immunogen affinity purified
Buffer PBS
Preservative 0.02% Sodium Azide
Restrictions For Research Use only

Publications
Application Details Alternatives back to top

Shu, Hu, Johnson: "TALL-1 is a novel member of the TNF family that is down-regulated by mitogens." in: Journal of leukocyte biology, Vol. 65, Issue 5, pp. 680-3, 1999 (PubMed).

Schneider, MacKay, Steiner et al.: "BAFF, a novel ligand of the tumor necrosis factor family, stimulates B cell growth." in: The Journal of experimental medicine, Vol. 189, Issue 11, pp. 1747-56, 1999 (PubMed).

Moore, Belvedere, Orr et al.: "BLyS: member of the tumor necrosis factor family and B lymphocyte stimulator." in: Science (New York, N.Y.), Vol. 285, Issue 5425, pp. 260-3, 1999 (PubMed).

Alternatives
Application Details Publications back to top

Alternatives for antigen "Tumor Necrosis Factor Receptor Superfamily, Member 17 (TNFRSF17)", type "Antibodies"
Hosts Rabbit (37), Rat (4), Mouse (1)
Reactivities Human (37), Mouse (Murine) (24), Rat (Rattus) (19)
Applications Western Blotting (WB) (24), Flow Cytometry (FACS) (20), Immunofluorescence (IF) (17), ELISA (15), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (8), Immunohistochemistry (IHC) (7), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (3), Immunoprecipitation (IP) (3), Blocking Antibody (Inhibition) (2), Immunocytochemistry (ICC) (2), Functional Studies (Func) (1), Immunoelectron Microscopy (IEM) (1)
Conjugates Biotin (2), Alexa Flour 488 (1), Alexa Fluor 350 (1), Alexa Fluor 488 (1), Alexa Fluor 555 (1), Alexa Fluor 647 (1), Cy3 (1), Cy5 (1), Cy5.5 (1), Cy7 (1), FITC (1), Gold (1), HRP (1), PE (1), PE,Cy3 (1), PE,Cy5 (1), PE,Cy5.5 (1), PE,Cy7 (1)
Epitopes C-Term (8), Center (1)