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|+1 404 474 4654|
|+1 888 205 9894 (TF)|
Tumor Necrosis Factor Receptor Superfamily, Member 17 (TNFRSF17) antibody
|Synonyms||BCM, BCMA, CD269, TNFRSF17|
Alternatives Western Blotting (WB)
|3 references available|
|Quantity||0.1 mg (0.5 mg/ml)|
|Price||Product not available in this region.|
|Alternative name||CD269 / BCMA|
|Immunogen||Synthetic peptide (Human).|
|Description||Members in the TNF superfamily regulate immune responses and induce apoptosis. Two novel members in the TNF family were recently identified and designated BAFF/BLyS/TALL1/THANK/zTNF4 and April/TALL2, respectively. BAFF was characterized as a B cell activator since it induced B cell proliferation and immunoglobulin secretion. April regulates immunological and non immunological cell growth. Three receptors, BCMA (for B cell maturation protein), TACI, and BAFFR, for BAFF were recently identified. BCMA, like TACI, binds BAFF and April. BAFF and its receptors induce B cell development and survival, activate NF-kappaB and c-jun N-terminal kinase, and are involved in B cell associated autoimmune diseases.|
|Application Notes||WB: Use at a concentration of 2-5 ug/ml. A band of approximately 27 kD is detected using K562 cell lysate as a positive control. Optimal dilutions/concentrations should be determined by the end user.|
|Purification||Immunogen affinity purified|
|Preservative||0.02% Sodium Azide|
|Restrictions||For Research Use only|
Shu, Hu, Johnson: "TALL-1 is a novel member of the TNF family that is down-regulated by mitogens." in: Journal of leukocyte biology, Vol. 65, Issue 5, pp. 680-3, 1999 (PubMed).
Schneider, MacKay, Steiner et al.: "BAFF, a novel ligand of the tumor necrosis factor family, stimulates B cell growth." in: The Journal of experimental medicine, Vol. 189, Issue 11, pp. 1747-56, 1999 (PubMed).
Moore, Belvedere, Orr et al.: "BLyS: member of the tumor necrosis factor family and B lymphocyte stimulator." in: Science (New York, N.Y.), Vol. 285, Issue 5425, pp. 260-3, 1999 (PubMed).
|Hosts||Rabbit (37), Rat (4), Mouse (1)|
|Reactivities||Human (37), Mouse (Murine) (24), Rat (Rattus) (19)|
|Applications||Western Blotting (WB) (24), Flow Cytometry (FACS) (20), Immunofluorescence (IF) (17), ELISA (15), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (8), Immunohistochemistry (IHC) (7), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (3), Immunoprecipitation (IP) (3), Blocking Antibody (Inhibition) (2), Immunocytochemistry (ICC) (2), Functional Studies (Func) (1), Immunoelectron Microscopy (IEM) (1)|
|Conjugates||Biotin (2), Alexa Flour 488 (1), Alexa Fluor 350 (1), Alexa Fluor 488 (1), Alexa Fluor 555 (1), Alexa Fluor 647 (1), Cy3 (1), Cy5 (1), Cy5.5 (1), Cy7 (1), FITC (1), Gold (1), HRP (1), PE (1), PE,Cy3 (1), PE,Cy5 (1), PE,Cy5.5 (1), PE,Cy7 (1)|
|Epitopes||C-Term (8), Center (1)|