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Tumor Necrosis Factor Receptor Superfamily, Member 17 (TNFRSF17) antibody

Details for Product No. ABIN150438, Supplier: Login to see
Antigen
  • TNFRSF17
  • BCM
  • BCMA
  • CD269
  • TNFRSF13A
  • Tnfrsf13
  • Tnfrsf13a
Reactivity
Human
91
18
7
Host
Rabbit
67
21
15
Clonality
Polyclonal
Conjugate
Un-conjugated
7
6
5
4
2
2
1
Application
Western Blotting (WB)
81
60
19
16
8
7
5
4
3
2
2
1
1
1
1
1
1
1
Supplier
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Immunogen Synthetic peptide (Human).
Isotype IgG
Characteristics Cellular Localization: Cell Membrane
Purification Immunogen affinity purified.
Alternative Name CD269 / BCMA (TNFRSF17 Antibody Abstract)
Background Members in the TNF superfamily regulate immune responses and induce apoptosis. Two novel members in the TNF family were recently identified and designated BAFF/BLyS/TALL1/THANK/zTNF4 and April/TALL2, respectively. BAFF was characterized as a B cell activator since it induced B cell proliferation and immunoglobulin secretion. April regulates immunological and non immunological cell growth. Three receptors, BCMA (for B cell maturation protein), TACI, and BAFFR, for BAFF were recently identified. BCMA, like TACI, binds BAFF and April. BAFF and its receptors induce B cell development and survival, activate NF-kappaB and c-jun N-terminal kinase, and are involved in B cell associated autoimmune diseases.
Synonyms: BCMA, TNFRSF17, Q02223, 109545, BCM, 608
Pathways
Application Notes WB: Use at a concentration of 2-5 ug/ml. A band of approximately 27 kD is detected using K562 cell lysate as a positive control. Optimal dilutions/concentrations should be determined by the end user.
Comment

Positive Controls: Human spleen tissue lysate, K562 or U937 whole cell lysates.

Restrictions For Research Use only
Format Liquid
Concentration 1 mg/mL
Buffer Preservative: 0.02% Sodium Azide, Constituents: PBS
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment Keep as concentrated solution, aliquot and store at 4°C.
Background publications Moore, Belvedere, Orr et al.: "BLyS: member of the tumor necrosis factor family and B lymphocyte stimulator." in: Science (New York, N.Y.), Vol. 285, Issue 5425, pp. 260-3, 1999 (PubMed).

Schneider, MacKay, Steiner et al.: "BAFF, a novel ligand of the tumor necrosis factor family, stimulates B cell growth." in: The Journal of experimental medicine, Vol. 189, Issue 11, pp. 1747-56, 1999 (PubMed).

Shu, Hu, Johnson: "TALL-1 is a novel member of the TNF family that is down-regulated by mitogens." in: Journal of leukocyte biology, Vol. 65, Issue 5, pp. 680-3, 1999 (PubMed).

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