Tumor Necrosis Factor Receptor Superfamily, Member 17 (TNFRSF17) antibody

Details for Product No. ABIN150438
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Antigen
Synonyms TNFRSF17, BCM, BCMA, CD269, TNFRSF13A, Tnfrsf13, Tnfrsf13a
Reactivity
Human
(66), (24), (17)
Host
Rabbit
(60), (8), (5)
Clonality
Polyclonal
Conjugate
Un-conjugated
(3), (3), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(52), (33), (14), (11), (9), (9), (5), (5), (4), (3), (2), (1), (1), (1)
Pubmed 3 references available
Quantity 0.1 mg
Shipping to United States (Change)
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Catalog No. ABIN150438
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Immunogen Synthetic peptide (Human).
Isotype IgG
Characteristics Cellular Localization: Cell Membrane
Purification Immunogen affinity purified.
Alternative Name CD269 / BCMA
Background Members in the TNF superfamily regulate immune responses and induce apoptosis. Two novel members in the TNF family were recently identified and designated BAFF/BLyS/TALL1/THANK/zTNF4 and April/TALL2, respectively. BAFF was characterized as a B cell activator since it induced B cell proliferation and immunoglobulin secretion. April regulates immunological and non immunological cell growth. Three receptors, BCMA (for B cell maturation protein), TACI, and BAFFR, for BAFF were recently identified. BCMA, like TACI, binds BAFF and April. BAFF and its receptors induce B cell development and survival, activate NF-kappaB and c-jun N-terminal kinase, and are involved in B cell associated autoimmune diseases.
Synonyms: BCMA, TNFRSF17, Q02223, 109545, BCM, 608
Application Notes WB: Use at a concentration of 2-5 ug/ml. A band of approximately 27 kD is detected using K562 cell lysate as a positive control. Optimal dilutions/concentrations should be determined by the end user.
Comment

Positive Controls: Human spleen tissue lysate, K562 or U937 whole cell lysates.

Restrictions For Research Use only
Format Liquid
Concentration 1 mg/mL
Buffer Preservative: 0.02% Sodium Azide, Constituents: PBS
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment Keep as concentrated solution, aliquot and store at 4°C.
General Shu, Hu, Johnson: "TALL-1 is a novel member of the TNF family that is down-regulated by mitogens." in: Journal of leukocyte biology, Vol. 65, Issue 5, pp. 680-3, 1999 (PubMed).

Schneider, MacKay, Steiner et al.: "BAFF, a novel ligand of the tumor necrosis factor family, stimulates B cell growth." in: The Journal of experimental medicine, Vol. 189, Issue 11, pp. 1747-56, 1999 (PubMed).

Moore, Belvedere, Orr et al.: "BLyS: member of the tumor necrosis factor family and B lymphocyte stimulator." in: Science (New York, N.Y.), Vol. 285, Issue 5425, pp. 260-3, 1999 (PubMed).

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