Tumor Necrosis Factor Receptor Superfamily, Member 17 (TNFRSF17) antibody

Details for Product No. ABIN150438
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Antigen
Synonyms BCM, BCMA, CD269, TNFRSF13A, Tnfrsf13, Tnfrsf13a, TNFRSF17
Reactivity
Human
(60), (25), (17)
Host
Rabbit
(57), (6), (5)
Clonality
Polyclonal
Conjugate
Un-conjugated
(2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(47), (33), (20), (13), (10), (10), (5), (5), (4), (3), (2), (1), (1), (1)
Pubmed 3 references available
Catalog no. ABIN150438
Quantity 0.1 mg
Price
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Immunogen Synthetic peptide (Human).
Isotype IgG
Purification Immunogen affinity purified
Alternative Name CD269 / BCMA
Background Members in the TNF superfamily regulate immune responses and induce apoptosis. Two novel members in the TNF family were recently identified and designated BAFF/BLyS/TALL1/THANK/zTNF4 and April/TALL2, respectively. BAFF was characterized as a B cell activator since it induced B cell proliferation and immunoglobulin secretion. April regulates immunological and non immunological cell growth. Three receptors, BCMA (for B cell maturation protein), TACI, and BAFFR, for BAFF were recently identified. BCMA, like TACI, binds BAFF and April. BAFF and its receptors induce B cell development and survival, activate NF-kappaB and c-jun N-terminal kinase, and are involved in B cell associated autoimmune diseases.
Application Notes WB: Use at a concentration of 2-5 ug/ml. A band of approximately 27 kD is detected using K562 cell lysate as a positive control. Optimal dilutions/concentrations should be determined by the end user.
Restrictions For Research Use only
Concentration 0.5 mg/ml
Buffer PBS
Preservative Sodium azide
General Shu, Hu, Johnson: "TALL-1 is a novel member of the TNF family that is down-regulated by mitogens." in: Journal of leukocyte biology, Vol. 65, Issue 5, pp. 680-3, 1999 (PubMed).

Schneider, MacKay, Steiner et al.: "BAFF, a novel ligand of the tumor necrosis factor family, stimulates B cell growth." in: The Journal of experimental medicine, Vol. 189, Issue 11, pp. 1747-56, 1999 (PubMed).

Moore, Belvedere, Orr et al.: "BLyS: member of the tumor necrosis factor family and B lymphocyte stimulator." in: Science (New York, N.Y.), Vol. 285, Issue 5425, pp. 260-3, 1999 (PubMed).

Hosts (57), (6), (5)
Reactivities (60), (25), (17)
Applications (47), (33), (20), (13), (10), (10), (5), (5), (4), (3), (2), (1), (1), (1)
Conjugates (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (17), (15), (5), (2), (2), (2)
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Add to Basket

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
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