RING1 and YY1 Binding Protein (RYBP) antibody

Details for Product No. ABIN150791
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Antigen
Synonyms AAP1, DEDAF, YEAF1, 2410018J24Rik, aap1, dedaf, yeaf1, cb337, rybp, wu:fi34f03
Reactivity
Human
(61), (32), (29), (12), (12), (11), (2), (2)
Host
Rabbit
(50), (12)
Clonality
Polyclonal
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(52), (13), (10), (9), (9), (7), (6), (5), (1), (1)
Pubmed 2 references available
Catalog no. ABIN150791
Quantity 50 µg
Price
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Immunogen Available on request
Isotype IgG
Specificity This antibody detects ~32kDa DEDAF.
Cross-Reactivity Mouse (Murine), Rat (Rattus)
Purification Immunogen affinity purified
Alternative Name RYBP
Background Cell death signal are transduced by Death Domain (DD), Death Effector Domain (DED), and Caspase Recruitment Domain (CARD) containing molecules. A novel protein that interacts with DED of caspase-8 and -10, and FADD was recently identified and designated DEDAF (for DED associated factor). DEDAF is identical to the transcriptional repressor RYBP. DEDAF interacts with FADD and augments the formation of CD95/FADD/caspase-8 complexes at the cytoplasm. DEDAF also interacts with DED-containing DNA binding protein (DEDD) in the nucleus, indicating it is involved in the regulation of both cytoplasmic and nuclear events of apoptosis.
Application Notes WB: Use at a concentration of 1.0 ug/ml. Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user.
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/ml
Buffer PBS pH 7.2 with 50% glycerol
Preservative Sodium azide
Storage -20 °C
General Lefkowitz: "Identification of adenylate cyclase-coupled beta-adrenergic receptors with radiolabeled beta-adrenergic antagonists." in: Biochemical pharmacology, Vol. 24, Issue 18, pp. 1651-8, 1976 (PubMed).

Kawai, Nomura, Hoshino et al.: "Death-associated protein kinase 2 is a new calcium/calmodulin-dependent protein kinase that signals apoptosis through its catalytic activity." in: Oncogene, Vol. 18, Issue 23, pp. 3471-80, 1999 (PubMed).

Hosts (50), (12)
Reactivities (61), (32), (29), (12), (12), (11), (2), (2)
Applications (52), (13), (10), (9), (9), (7), (6), (5), (1), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (7), (5), (4), (3), (2), (1), (1), (1)
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