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Details for Product No. ABIN150791

RING1 and YY1 Binding Protein (RYBP) antibody

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Synonyms AAP1, DEDAF, YEAF1, 2410018J24Rik, aap1, dedaf, yeaf1, cb337, rybp, wu:fi34f03
»Alternatives Human
»Alternatives Rabbit
Clonality Polyclonal
»Alternatives Un-conjugated
»Alternatives Western Blotting (WB)
Pubmed 2 references available
Catalog no. ABIN150791
Quantity 50 µg
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Immunogen Available on request
Isotype IgG
Specificity This antibody detects ~32kDa DEDAF.
Cross-Reactivity Mouse (Murine), Rat (Rattus)
Purification Immunogen affinity purified
Alternative Name RYBP
Background Cell death signal are transduced by Death Domain (DD), Death Effector Domain (DED), and Caspase Recruitment Domain (CARD) containing molecules. A novel protein that interacts with DED of caspase-8 and -10, and FADD was recently identified and designated DEDAF (for DED associated factor). DEDAF is identical to the transcriptional repressor RYBP. DEDAF interacts with FADD and augments the formation of CD95/FADD/caspase-8 complexes at the cytoplasm. DEDAF also interacts with DED-containing DNA binding protein (DEDD) in the nucleus, indicating it is involved in the regulation of both cytoplasmic and nuclear events of apoptosis.
Application Notes WB: Use at a concentration of 1.0 ug/ml. Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user.
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/ml
Buffer PBS pH 7.2 with 50% glycerol
Preservative Sodium azide
Storage -20 °C
Lefkowitz: "Identification of adenylate cyclase-coupled beta-adrenergic receptors with radiolabeled beta-adrenergic antagonists." in: Biochemical pharmacology, Vol. 24, Issue 18, pp. 1651-8, 1976 (PubMed).

Kawai, Nomura, Hoshino et al.: "Death-associated protein kinase 2 is a new calcium/calmodulin-dependent protein kinase that signals apoptosis through its catalytic activity." in: Oncogene, Vol. 18, Issue 23, pp. 3471-80, 1999 (PubMed).

Alternatives for antigen "RING1 and YY1 Binding Protein (RYBP)", type "Antibodies"
Hosts (50), (11)
Reactivities (60), (31), (28), (12), (12), (11), (2), (2)
Applications (51), (13), (11), (9), (8), (6), (6), (3), (1), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (7), (7), (4), (4), (2), (1), (1), (1)