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Details for Product No. ABIN151055

Aryl Hydrocarbon Receptor Nuclear Translocator (ARNT) antibody

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Antigen
Synonyms HIF-1-beta, HIF-1beta, HIF1-beta, HIF1B, HIF1BETA, TANGO, bHLHe2, D3Ertd557e, Drnt, ESTM42, Hif1b, W08714, mKIAA4051, Arnt1, ARNT, zgc:136664, arnt1, hif1b, tango, xArnt, hif1beta, hif-1beta, AHA-1
Reactivity
»Alternatives Cow (Bovine), Ferret, Human, Mouse (Murine), Rat (Rattus), Sheep (Ovine)
Host
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
Pubmed 12 references available
Catalog no. ABIN151055
Quantity 0.1 mL
Price
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Immunogen Fusion protein containing amino acids 496-789 of human HIF-1 beta.
Clone H1beta234
Isotype IgG1
Specificity This antibody is specific for HIF 1 beta /ARNT. Species Reactivity: Human, bovine, sheep, mouse, rat and ferret. Other species have not been tested.
Cross-Reactivity Cow (Bovine), Human, Mouse (Murine), Rat (Rattus), Sheep (Ovine)
Purification Purified
Alternative Name HIF1 beta / ARNT
Background Hypoxia contributes significantly to the pathophysiology of major categories of humandisease, including myocardial and cerebral ischemia, cancer, pulmonary hypertension,congenital heart disease, and chronic obstructive pulmonary disease. HIF-1 is a nuclear protein involved in mammalian oxygen homeostasis. This occurs as aposttranslational modification by prolyl hydroxylation. HIF-1 is a heterodimer composedof HIF-1 alpha and HIF-1 beta subunits. Both subunits are constantly translated.However, under normoxic conditions, human HIF-1 alpha is hydroxylated at Pro402 orPro564 by a set of HIF prolyl hydroxylases, is polyubiquinated, and eventually degradedin proteosomes. Under hypoxic conditions, the lack of hydroxylation prevents HIFdegradation and increases transcriptional activity. Therefore, the concentration of HIF-1alpha increases in the cell. In contrast, HIF-1 beta remains stable under either condition.HIF-1 beta is a series of aryl hydrocarbon receptor nuclear translocator (ARNT) geneproducts. Alternate Names: anti-ARNT antibody, anti-Aryl Hydrocarbon Receptor Nuclear Translocator antibody,anti-Dioxin Receptor antibody, anti-Hypoxia Inducible Factor 1 antibody, anti-Tangoantibody, anti-HIF1 beta antibody, anti-HIF1beta antibody.
Gene ID 405, 11863, 25242
UniProt P27540
Research Area Transcription Factors
Application Notes Suggested working dilutions: Western Blot 1:500,Immunohistochemistry-Paraffin 1:100
Restrictions For Research Use only
Format Liquid
Concentration 1.4 mg/ml
Buffer PBS. Preservative: 0.05% sodium azide
Preservative Sodium azide
Storage -20 °C
Bernaudin, Tang, Reilly et al.: "Brain genomic response following hypoxia and re-oxygenation in the neonatal rat. Identification of genes that might contribute to hypoxia-induced ischemic tolerance." in: The Journal of biological chemistry, Vol. 277, Issue 42, pp. 39728-38, 2002 (PubMed).

Elvert, Kappel, Heidenreich et al.: "Cooperative interaction of hypoxia-inducible factor-2alpha (HIF-2alpha ) and Ets-1 in the transcriptional activation of vascular endothelial growth factor receptor-2 (Flk-1)." in: The Journal of biological chemistry, Vol. 278, Issue 9, pp. 7520-30, 2003 (PubMed).

Mabjeesh, Willard, Harris et al.: "Dibenzoylmethane, a natural dietary compound, induces HIF-1 alpha and increases expression of VEGF." in: Biochemical and biophysical research communications, Vol. 303, Issue 1, pp. 279-86, 2003 (PubMed).

Mabjeesh, Escuin, LaVallee et al.: "2ME2 inhibits tumor growth and angiogenesis by disrupting microtubules and dysregulating HIF." in: Cancer cell, Vol. 3, Issue 4, pp. 363-75, 2003 (PubMed).

Kasuno, Takabuchi, Fukuda et al.: "Nitric oxide induces hypoxia-inducible factor 1 activation that is dependent on MAPK and phosphatidylinositol 3-kinase signaling." in: The Journal of biological chemistry, Vol. 279, Issue 4, pp. 2550-8, 2004 (PubMed).

Alam, Maizels, Park et al.: "Follicle-stimulating hormone activation of hypoxia-inducible factor-1 by the phosphatidylinositol 3-kinase/AKT/Ras homolog enriched in brain (Rheb)/mammalian target of rapamycin (mTOR) pathway is necessary for induction of select protein markers of follic" in: The Journal of biological chemistry, Vol. 279, Issue 19, pp. 19431-40, 2004 (PubMed).

Arsham, Plas, Thompson et al.: "Akt and hypoxia-inducible factor-1 independently enhance tumor growth and angiogenesis." in: Cancer research, Vol. 64, Issue 10, pp. 3500-7, 2004 (PubMed).

Hirota, Fukuda, Takabuchi et al.: "Induction of hypoxia-inducible factor 1 activity by muscarinic acetylcholine receptor signaling." in: The Journal of biological chemistry, Vol. 279, Issue 40, pp. 41521-8, 2004 (PubMed).

Amir, Wang, Matzkin et al.: "MSF-A interacts with hypoxia-inducible factor-1alpha and augments hypoxia-inducible factor transcriptional activation to affect tumorigenicity and angiogenesis." in: Cancer research, Vol. 66, Issue 2, pp. 856-66, 2006 (PubMed).

Hui, Bauer, Striet et al.: "Calcium signaling stimulates translation of HIF-alpha during hypoxia." in: The FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 20, Issue 3, pp. 466-75, 2006 (PubMed).

Nakamura, Martin, Jackson et al.: "Brain-derived neurotrophic factor activation of TrkB induces vascular endothelial growth factor expression via hypoxia-inducible factor-1alpha in neuroblastoma cells." in: Cancer research, Vol. 66, Issue 8, pp. 4249-55, 2006 (PubMed).

Asikainen, Chang, Coalson et al.: "Improved lung growth and function through hypoxia-inducible factor in primate chronic lung disease of prematurity." in: The FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 20, Issue 10, pp. 1698-700, 2006 (PubMed).

Alternatives for antigen "Aryl Hydrocarbon Receptor Nuclear Translocator (ARNT)", type "Antibodies"
Hosts (47), (37), (1)
Reactivities (81), (44), (39), (27), (15), (15), (13), (12), (3), (1), (1)
Applications (69), (30), (22), (20), (10), (10), (8), (5), (5), (2), (1), (1), (1), (1), (1)
Conjugates (3), (3), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (8), (7), (5), (4), (4), (3), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
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