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|+1 404 474 4654|
|+1 888 205 9894 (TF)|
Clock Homolog (Mouse) (CLOCK) antibody
|Synonyms||KAT13D, bHLHe8, KIAA0334, mKIAA0334, 5330400M04Rik, clk, Xclk, XClock, CLOCK, DKFZp469L011, zCLOCK1, zfCLOCK1, CLK, Jerk, Jrk, PAS1, dCLK, dCLK/JRK, dCLOCK, dClck, DmelCG7391, CG7391|
Human, Mouse (Murine)
Alternatives Chromatin Immunoprecipitation (ChIP), Western Blotting (WB)
|4 references available|
|Quantity||0.1 mL (Variants)|
|Price||Product not available in this region.|
|Immunogen||Two peptides derived from mouse CLOCK conjugated to albumin.|
|Cross-Reactivity||Human, Mouse (Murine)|
|Description||CLOCK, a basic helix-loop-helix (bHLH)/PAS protein, is an important factor in themolecular clock mechanism. Mutations in this protein lead to abnormal circadianbehavior and defective transcriptional activity. CLOCK has been shown to interactstrongly with other bHLH-PAS proteins such as MOP3, a BMAL1 isoform. Alternate Names: anti-KIAA0334 antibody, anti-KAT13D antibody, anti-ChIp Grade antibody, anti KAT13D/ CLOCK antibody.|
|Specificity||This antibody is specific for CLOCK. Species Reactivity: Peptide 1 shows significant homology to human and Gallus gallus. Peptide 2 shows82% homology to Gallus gallus. Localization: Cytoplasmic and Nuclear. Shuffling between the cytoplasm and the nucleus is undercircadian regulation and is BMAL1-dependent. Phosphorylated form located in thenucleus.|
|Application Notes||Western Blot 1:1000|
|Buffer||Preservative: Sodium Azide.|
|Storage||Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.|
|Research Area||Cardiovascular, Atherosclerosis, Transcription Factors, Metabolism|
|Restrictions||For Research Use only|
|Lanes 3-5 contained alpha CLOCK immunoprecipitated DNA (15, 10 and 5 ul of antisera added respectively to the 900 ul of sonicated chromatin sample in the ChIP assay.|
Hogenesch, Gu, Jain et al.: "The basic-helix-loop-helix-PAS orphan MOP3 forms transcriptionally active complexes with circadian and hypoxia factors." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 95, Issue 10, pp. 5474-9, 1998 (PubMed).
Jin, Shearman, Weaver et al.: "A molecular mechanism regulating rhythmic output from the suprachiasmatic circadian clock." in: Cell, Vol. 96, Issue 1, pp. 57-68, 1999 (PubMed).
Shearman, Weaver: "Photic induction of Period gene expression is reduced in Clock mutant mice." in: Neuroreport, Vol. 10, Issue 3, pp. 613-8, 1999 (PubMed).
Muunoz, Brewer, Baler: "Circadian Transcription. Thinking outside the E-Box." in: The Journal of biological chemistry, Vol. 277, Issue 39, pp. 36009-17, 2002 (PubMed).