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Details for Product No. ABIN151068

Aralkylamine N-Acetyltransferase (AANAT) antibody

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Antigen
Synonyms DSPS, SNAT, AA-NAT, Nat-2, Nat4, Snat
Reactivity
»Alternatives Human
Host
»Alternatives Rabbit
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Immunofluorescence (IF), Western Blotting (WB)
Pubmed 2 references available
Catalog no. ABIN151068
Quantity 0.1 mL
Price
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Immunogen Human AANAT. Reference Sequence: U40347.
Specificity This antibody is specific for primate AANAT (3,4). Species Reactivity: Recognizes human and rhesus AANAT. It does not recognize rat, ovine, chicken orzebrafish AANAT.
Cross-Reactivity Human, Monkey
Purification Purified
Alternative Name Serotonin acetylase
Background Arylalkylamine N-Acetyltransferase (AANAT) is the penultimate enzyme is melatoninsynthesis. Hormonal melatonin has been implicated in sleep and circadian clockfunction, and acts asthe hormone of the night. Large changes in theabundance of AANAT are believed to be responsible for the large day/night rhythms inmelatonin synthesis in the pineal gland and retina (1,2).Most research shows that AANAT activity is regulated by controlling the steady-statelevels of the protein. Recent research, however, suggests that another mechanism mayalso play a role in controlling melatonin production without altering AANAT protein andactivity. This mechanism may explain the sudden physiological increase in circulatingmelatonin observed at the onset of the dark period in humans (3). Alternate Names: anti-Arylalkamine N-Acetyltransferase antibody, anti-Serotonin-N-Acetyltransferaseantibody, anti-SNAT antibody.
Gene ID 15, 25120
UniProt U40347
Research Area Enzymes
Application Notes Suggested working dilutions: Western Blot 1:500-1:1000,Immunocytochemistry 1:200
Restrictions For Research Use only
Buffer Immunopurified rabbit antiserum (100 ul). The peptide (hAANAT1-26) was bound tostrips of PVDF membrane. The antiserum was eluted in 0.1N glacial acetic acidcontaining 0.1% BSA and neutralized using 10X PBS containing NaOH to a final pH of6.8.
Storage 4 °C
Iuvone, Brown, Haque et al.: "Retinal melatonin production: role of proteasomal proteolysis in circadian and photic control of arylalkylamine N-acetyltransferase." in: Investigative ophthalmology & visual science, Vol. 43, Issue 2, pp. 564-72, 2002 (PubMed).

Klein, Ganguly, Coon et al.: "14-3-3 proteins in pineal photoneuroendocrine transduction: how many roles?" in: Journal of neuroendocrinology, Vol. 15, Issue 4, pp. 370-7, 2003 (PubMed).

Alternatives for antigen "Aralkylamine N-Acetyltransferase (AANAT)", type "Antibodies"
Hosts (50)
Reactivities (44), (32), (28), (24), (12), (12), (6), (1), (1), (1), (1)
Applications (32), (20), (7), (7), (6), (5)
Conjugates (4), (4), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1)
Epitopes (15), (4), (3), (2), (2), (2), (2)
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