Cbp/p300-Interacting Transactivator, with Glu/Asp-Rich Carboxy-terminal Domain, 2 (CITED2) antibody

Antigen: Cbp/p300-Interacting Transactivator, with Glu/Asp-Rich Carboxy-terminal Domain, 2 (CITED2)

Synonyms: MRG1, P35SRJ, Mrg1, Msg2, p35srj, AI835299, ER154-like, MGC93288, CITED2, mrg1, MGC75612, cited2, MGC140571, cite2

Clonality: Monoclonal (JA22)

Host: Mouse

Reactivity: Human

Application: Western Blotting (WB)

Catalog no.: ABIN151069

Additional Information

Alternative name: CITED2

Gene ID: 10370

UniProt: Q99967

Immunogen: Human CITED 2 protein.

Cross-Reactivity: Human, Mouse (Murine)

Format: Ascites

Isotype: IgG1

Clone: JA22

Description: Cited 2 is a cAMP-responsive element-binding protein (CBP)/p300 interactingtranscriptional modulator and a proposed negative regulator for hypoxia-induciblefactor-1 alpha. Recruitment of CBP/p300 by HIF-1 is essential for the transcriptionalresponse to hypoxia. Alternate Names: anti-CITED2 antibody, anti-Cbp/p300-interacting transactivator antibody, anti-withGlu/Asp-rich carboxy-terminal domain antibody, anti-2antibody, anti-HGNC:1987antibody, anti-MRG1 antibody, anti-P35SRJ antibody, anti-CITED 2 antibody.

Specificity: This antibody is specific for CITED 2. Species Reactivity: Human. Does not work well on mouse. Other species have not been tested. Localization: Nuclear.

Application Details

Application Notes: Suggested working dilutions: Western Blot 1:500

Concentration: 22.4 mg/ml

Purification: Ascites

Buffer: Preservative: Sodium Azide.

Storage: Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.

Research Area: Cancer

Restrictions: For Research Use only

Publications

Bhattacharya, Michels, Leung et al.: "Functional role of p35srj, a novel p300/CBP binding protein, during transactivation by HIF-1." in: Genes & development, Vol. 13, Issue 1, pp. 64-75, 1999 (PubMed).

Leung, Jones, Michels et al.: "Molecular cloning and chromosomal localization of the human CITED2 gene encoding p35srj/Mrg1." in: Genomics, Vol. 61, Issue 3, pp. 307-13, 2000 (PubMed).

Yin, Haynie, Yang et al.: "The essential role of Cited2, a negative regulator for HIF-1alpha, in heart development and neurulation." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 16, pp. 10488-93, 2002 (PubMed).

Tien, Davis, Vanden Heuvel: "Identification of the CREB-binding protein/p300-interacting protein CITED2 as a peroxisome proliferator-activated receptor alpha coregulator." in: The Journal of biological chemistry, Vol. 279, Issue 23, pp. 24053-63, 2004 (PubMed).

Bamforth, Braganuca, Farthing et al.: "Cited2 controls left-right patterning and heart development through a Nodal-Pitx2c pathway." in: Nature genetics, Vol. 36, Issue 11, pp. 1189-96, 2004 (PubMed).

Haase, Schott, Bornstein et al.: "CITED2 is expressed in human adrenocortical cells and regulated by basic fibroblast growth factor." in: The Journal of endocrinology, Vol. 192, Issue 2, pp. 459-65, 2007 (PubMed).

Dabir, Marinic, Krukovets et al.: "Aryl hydrocarbon receptor is activated by glucose and regulates the thrombospondin-1 gene promoter in endothelial cells." in: Circulation research, Vol. 102, Issue 12, pp. 1558-65, 2008 (PubMed).